Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence
Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence
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DOI：
10.1039/b810978h
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Peacock, Robert D.
中科院分区：
文献类型：
--
作者：
Montgomery, Craig P.;New, Elizabeth J.;Peacock, Robert D.
Tb和Eu(III)络合物的(SSS)-Delta对映体的螺旋性在可逆结合到血清白蛋白的“药物位II”上时反转，通过其环极化发射中的开关发出信号；(RRR)-Lambda络合物没有这种行为，从而定义了白蛋白结合的独特手性探针。
The helicity of the (SSS)-Delta enantiomer of a terbium and europium(III) complex is inverted on reversible binding to 'drug site II' of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Lambda complexes, thereby defining a unique chiroptical probe of albumin binding.