Autochthonous sporadic acute hepatitis E caused by two distinct subgenotype 3b hepatitis E virus strains with only 90% nucleotide identity
Autochthonous sporadic acute hepatitis E caused by two distinct subgenotype 3b hepatitis E virus strains with only 90% nucleotide identity
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DOI：
10.1007/s12328-017-0718-3
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发表时间：
2017-02
影响因子：
1
通讯作者：
Yasuko Yamaguchi;H. Takagi;Yuhei Suzuki;Kyoko Maruhashi;T. Kosone;S. Kakizaki;Ken Sato;M. Yamada-M.-Ya
中科院分区：
文献类型：
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作者：
Yasuko Yamaguchi;H. Takagi;Yuhei Suzuki;Kyoko Maruhashi;T. Kosone;S. Kakizaki;Ken Sato;M. Yamada-M.-Ya
戊型肝炎是由戊型肝炎病毒（HEV）引起的，在日本是一个公共卫生问题，其中来自家猪和野猪的HEV的人畜共患食源性传播起着重要作用。一名44岁的日本男性，患有本土散发性急性戊型肝炎，因全身乏力和中度肝功能障碍入院。在本研究中，两种不同的戊型肝炎病毒株回收的病人，谁吃了生的或未煮熟的猪肝和猪肠每周两到三次，3个月前的疾病发作。分离株在3b亚型内分为两个群，其开放阅读框（ORF）1和ORF 2序列差异均在10%左右，表明HEV混合感染。由于在日本，大多数已报告的临床HEV感染患者是根据IgA类HEV抗体的检测进行诊断的，并且由于仅对有限数量的HEV感染患者的血清样本进行HEV RNA检测和核苷酸测序，因此HEV混合感染患者很可能仍然在很大程度上被忽视。确定本地HEV感染的来源仍然是一个重要的目标。需要继续努力追踪急性或慢性本地HEV感染的来源。
Hepatitis E, which is caused by hepatitis E virus (HEV), is a public health concern in Japan, where the zoonotic food-borne transmission of HEV from domestic pigs and wild boars plays an important role. A 44-year-old Japanese man with autochthonous sporadic acute hepatitis E was admitted with general fatigue and moderate liver dysfunction. In the present study, two distinct HEV strains were recovered from the patient, who had consumed the raw or undercooked pig liver and intestine two or three times per week for 3 months before the disease onset. The recovered HEV strains were segregated into two clusters within subgenotype 3b, the open reading frame (ORF)1 and ORF2 sequences of which each showed ~10% difference, indicating HEV mixed infection. Because most notified patients with clinical HEV infection in Japan are diagnosed based on the detection of IgA-class HEV antibodies and because serum samples from only a limited number of HEV-infected patients are subjected to HEV RNA detection and nucleotide sequencing, it is very likely that patients with HEV mixed infection remain largely overlooked. The identification of sources of autochthonous HEV infection remains an important goal. Continued efforts to trace the sources of acute or chronic autochthonous HEV infection are warranted.