Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment
Regional Homogeneity and Multivariate Pattern Analysis of Cervical Spondylosis Neck Pain and the Modulation Effect of Treatment
复制标题
颈椎病颈痛的区域同质性、多变量模式分析及治疗调节效果
DOI：
10.3389/fnins.2018.00900
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发表时间：
2018-12-06
影响因子：
4.3
通讯作者：
Kong, Jian
中科院分区：
文献类型：
--
作者：
Chen, Jun;Wang, Zengjian;Kong, Jian
目的：观察慢性颈椎病颈痛(CSNP)患者脑功能的变化，并与健康对照组(HCS)进行比较，探讨其干预效果。方法：纳入104例CSNP患者和96例相匹配的HCS患者。患者接受为期4周的治疗。治疗前后分别采集静息功能磁共振成像和Northwick Park颈部疼痛问卷(NPQ)。采用静息状态区域同质性分析(rS-REHO)和多变量模式分析(MVPA)研究CSNP患者和对照组的rS-REHO差异和纵向治疗的效果；(2)对CSNP患者和HCS患者进行分类，并预测MVPA治疗前的临床结果。结果：(1)CSNP患者左侧感觉运动皮质和右侧颞顶交界处(RTPJ)的rS-ReHO降低，rTPJ处的rS-ReHO在治疗后显著升高；(2)基线时rTPJ处的rS-ReHO与NPQ相关，治疗前后rTPJ处的rS-ReHO变化与NPQ变化相关；(3)MVPA可以区分CSNP和HCS患者，准确率为72%，预测临床预后的平均绝对误差为19.6%。结论：CSNP患者存在rTPJ和感觉运动区功能障碍。意义：rTPJ在CSNP的病理生理过程中起重要作用。
Objects: We investigated brain functional alteration in patients with chronic cervical spondylosis neck pain (CSNP) compared to healthy controls (HCs) and the effect of intervention. Methods: 104 CSNP patients and 96 matched HCs were recruited. Patients received 4 weeks of treatment. Resting-state fMRI and Northwick Park Neck Pain Questionnaire (NPQ) were collected before and after treatment. Resting state regional homogeneity (rs-ReHo) and multivariate pattern analysis (MVPA) were applied to (1) investigate rs-ReHo differences between CSNP patients and controls and the effect of longitudinal treatment and (2) classify CSNP patients from HCs and predict clinical outcomes before treatment using MVPA. Results: We found that (1) CSNP patients showed decreased rs-ReHo in the left sensorimotor cortex and right temporo-parietal junction (rTPJ), and rs-ReHo at the rTPJ significantly increased after treatment; (2) rs-ReHo at rTPJ was associated with NPQ at baseline, and pre- and post-treatment rs-ReHo changes at rTPJ were associated with NPQ changes in CSNP patients; and (3) MVPA could discriminate CSNP patients from HCs with 72% accuracy and predict clinical outcomes with a mean absolute error of 19.6%. Conclusion: CSNP patients are associated with dysfunction of the rTPJ and sensorimotor area. Significance: rTPJ plays on important role in the pathophysiology and development of CSNP.