Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold
Synthesis, material properties, and biocompatibility of a novel self-cross-linkable poly(caprolactone fumarate) as an injectable tissue engineering scaffold
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DOI：
10.1021/bm050206y
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发表时间：
2005-09-01
影响因子：
6.2
通讯作者：
Yaszemski, MJ
中科院分区：
文献类型：
--
作者：
Jabbari, E;Wang, SF;Yaszemski, MJ
一种新型的自交联可生物降解的大分子单体聚己内酯富马酸酯（PCLF）已被开发用于引导骨再生。该大分子单体是富马酰氯和聚己内酯的共聚物，富马酰氯含有用于原位交联的双键，聚己内酯具有柔性链以促进自交联性。采用傅里叶变换红外光谱、H-1和C-13核磁共振谱和凝胶渗透色谱对PCLF进行了表征。以氯化钠颗粒为致孔剂，采用化学引发体系制备多孔支架。用扫描电镜和显微计算机断层扫描对PCLF支架进行了表征。并对PCLF的细胞毒性和生物相容性进行评价。我们的研究结果表明，这种新型的共聚物，PCLF，是一种可注射的，自交叉，和生物相容性的大分子单体，可能会被用作组织工程应用的支架。
A novel self-cross-linkable and biodegradable macromer, poly(caprolactone fumarate) (PCLF), has been developed for guided bone regeneration. This macromer is a copolymer of fumaryl chloride, which contains double bonds for in-situ cross-linking, and poly(c-caprolactone), which has a flexible chain to facilitate self-cross-linkability. PCLF was characterized with Fourier transform infrared spectroscopy, H-1 and C-13 nuclear magnetic resonance spectroscopy, and gel permeation chromatography. Porous scaffolds were fabricated with sodium chloride particles as the porogen and a chemical initiation system. The PCLF scaffolds were characterized with scanning electron microscopy and micro-computed-tomography. The cytotoxicity and in vivo biocompatibility of PCLF were also assessed. Our results suggest that this novel copolymer, PCLF, is an injectable, self-cross-linkable, and biocompatible macromer that may be potentially used as a scaffold for tissue engineering applications.