Hydrogen Peroxide-induced Cell Death in Mammalian Cells.
Hydrogen Peroxide-induced Cell Death in Mammalian Cells.
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DOI：
10.33696/signaling.2.052
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Supattapone S
中科院分区：
文献类型：
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作者：
Chidawanyika T;Supattapone S
过氧化氢（H2O2）是一种重要的细胞内外信号分子，可以决定细胞的命运。在低浓度下，H2O2在增殖、免疫和代谢中发挥作用。细胞暴露于较高的非生理性浓度的H2O2会导致氧化应激。如果这种压力得不到缓解，细胞就会死亡。以往对h2o2诱导细胞死亡的关键介质的研究较少。利用CRISPR/Cas9工具的遗传筛选技术的进步使得深入的全基因组研究能够识别不同细胞类型中的关键介质。在这里，我们简要探讨H2O2在细胞中的作用和H2O2诱导细胞死亡的基本介质，重点关注核黄素，H2O2诱导细胞死亡的一个意想不到的基本介质。
Hydrogen peroxide (H2O2) is an important intra- and extra-cellular signaling molecule that can determine cell fate. At low concentrations, H2O2 plays roles in proliferation, immunity, and metabolism. Cellular exposure to higher non-physiologic concentrations of H2O2 can result in oxidative stress. If the stress is not alleviated, cell death can ensue. In the past, few studies were done to study the key mediators of H2O2-induced cell death. The advancement of genetic screening technology with CRISPR/Cas9 tools has allowed for in depth genome-wide studies to identify key mediators in different cell types. Here, we briefly explore the role of H2O2 in the cell and the essential mediators of H2O2-induced cell death with a focus on riboflavin, an unexpected essential mediator of H2O2-induced cell death.