ADENOCARCINOMA OF THE ENDOMETRIUM - SURVIVAL COMPARISONS OF PATIENTS WITH AND WITHOUT PELVIC NODE SAMPLING
ADENOCARCINOMA OF THE ENDOMETRIUM - SURVIVAL COMPARISONS OF PATIENTS WITH AND WITHOUT PELVIC NODE SAMPLING
复制标题
DOI：
10.1006/gyno.1995.1005
复制
发表时间：
1995-01-01
影响因子：
4.7
通讯作者：
CONNER, W
中科院分区：
文献类型：
--
作者：
KILGORE, LC;PARTRIDGE, EE;CONNER, W
从1969年到1990年，阿拉巴马大学伯明翰分校的妇科肿瘤学家对649名子宫内膜腺癌患者进行了手术治疗。所有患者均行TAH-BSO和洗涤。212例患者进行了多部位盆腔淋巴结取样（平均淋巴结数为11），205例患者进行了有限部位盆腔淋巴结取样（平均淋巴结数为4），208例患者未进行淋巴结取样。历史预后特征，包括肿瘤分级、浸润深度、附件转移、宫颈受累和细胞学阳性，在三组中分布均匀。平均随访3年。行多部位盆腔淋巴结取样的患者生存率明显高于未行盆腔淋巴结取样的患者（P = 0.0002）。当患者被分类为低风险（疾病局限于体）或高风险（疾病在子宫颈、附件、子宫浆膜或清洗）时，与没有淋巴结采样的患者相比，多部位盆腔淋巴结采样再次提供了显著的生存优势（高风险，P = 0.0006；低风险，P = 0.026）。在III级病变或深部肌层浸润接受全盆腔放疗的患者中，多部位盆腔淋巴结取样的患者比未取样盆腔淋巴结的患者生存率更高（P = 0.0027）。多部位淋巴结取样患者的显著生存优势，总体上和在高风险和低风险组中，强烈提示治疗益处。此外，辅助治疗可能更适合这些患者。(C) 1995学术出版社，Inc。
From 1969 to 1990, 649 patients with adenocarcinoma of the endometrium were surgically managed by gynecologic oncologists from the University of Alabama at Birmingham. All patients underwent TAH-BSO and washings. Two hundred twelve patients had multiple-site pelvic node sampling (mean number of nodes, 11), 205 patients had limited site pelvic node sampling (mean number of nodes, 4), and in 208 patients, nodes were not sampled. Historical prognostic features, including tumor grade, depth of invasion, adnexal metastasis, cervical involvement, and positive cytology, were equally distributed in the three groups. Mean follow-up was 3 years. Patients undergoing multiple-site pelvic node sampling had significantly better survival than patients without node sampling (P = 0.0002). When patients were categorized as low risk (disease confined to the corpus) or as high risk (disease in the cervix, adnexa, uterine serosa, or washings) multiple-site pelvic node sampling again provided a significant survival advantage compared to patients without node sampling (high risk, P = 0.0006; low risk, P = 0.026). In a comparison of patients receiving whole pelvic radiation for grade III lesions or deep myometrial invasion, patients with multiple-site pelvic node sampling had better survival than those in whome nodes were not sampled (P = 0.0027). The significant survival advantage for patients having multiple-site node sampling, overall and in high- and low-risk groups, strongly suggests a therapeutic benefit. Additionally, adjuvant therapy may be more appropriately directed in these patients. (C) 1995 Academic Press, Inc.