Pediatric Ototoxicity: Current Trends and Management
Pediatric Ototoxicity: Current Trends and Management
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DOI：
10.1055/s-0039-1684044
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发表时间：
2019-05-01
影响因子：
--
通讯作者：
Fligor, Brian J.
中科院分区：
文献类型：
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作者：
Fligor, Brian J.
对抗严重感染或恶性肿瘤的医疗干预措施具有显著的发病率，包括耳毒性。虽然这些救命药物通常是维持生命所必需的，但对幸存者生活质量的影响越来越引起家庭和医疗保健提供者的关注。对于医疗处方者来说，最重要的是适当敏感的耳毒性分级量表和听力学监测方案，以监测听力损失。分级量表的目的是帮助将复杂的听力学信息传达给非听力学家的医疗保健提供者（如肿瘤学家），以帮助他们做出关于化疗剂量的正确决定。适当的听力学监测有助于减少意外听力损失发作与诊断和干预之间的时间延迟。最后，小儿耳毒性分级和监测方案有助于确保及时获得足够的听力障碍，验证和确认儿童永久性药物引起的听力损失和耳鸣的管理。
Medical interventions to combat serious infection or malignancies carry significant morbidities, including ototoxicity. While these lifesaving drugs are often necessary to preserve life, the impact on quality of life for survivors is increasingly concerning for families and healthcare providers. Of primary importance for medical prescribers are appropriately sensitive ototoxicity grading scales and audiological monitoring protocols for surveillance for hearing loss. The intent of grading scales is to help communicate complicated audiological information to non-audiologist healthcare providers (such as oncologists) to help them make good decisions with regards to chemotherapy dosing. Appropriate audiological monitoring helps reduce the time delay between the adventitious onset of hearing loss and the diagnosis and intervention. Finally, pediatric ototoxicity grading and monitoring protocols help ensure timely access to adequate hearing habilitation, verification and validation of the management of permanent medication-induced hearing loss and tinnitus in children.