LACTATE PRODUCTION IN ADIPOSE-TISSUE - A REGULATED FUNCTION WITH EXTRA-ADIPOSE IMPLICATIONS
LACTATE PRODUCTION IN ADIPOSE-TISSUE - A REGULATED FUNCTION WITH EXTRA-ADIPOSE IMPLICATIONS
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DOI：
10.1096/fasebj.6.7.1563593
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发表时间：
1992-04-01
期刊：
影响因子：
4.8
通讯作者：
LOVEJOY, J
中科院分区：
文献类型：
--
作者：
DIGIROLAMO, M;NEWBY, FD;LOVEJOY, J
脂肪组织对全身葡萄糖代谢的定量贡献估计值以前报道为 1-3%，现已修正为 10-30% 左右。这些修订后的估计部分来自于认识到脂肪组织除了二氧化碳和甘油三酯之外，还利用葡萄糖产生乳酸和丙酮酸。脂肪组织产生的乳酸在体外受到葡萄糖、胰岛素和肾上腺素浓度变化的调节。在体内，乳酸的产生受到动物营养状态（进食或禁食）的急剧调节，并受到肥胖程度的长期调节。大鼠脂肪细胞大小与葡萄糖向乳酸的相对转化之间存在很强的正相关性（r = 0.89，P < 0.001）。糖尿病还与脂肪细胞中乳酸生成显着增加有关。肥胖或糖尿病大鼠（或人类）的脂肪细胞可以代谢为乳酸，其含量高达所摄取葡萄糖的 50-70%。从这些最近的研究中，我们发现脂肪器官可以在禁食期间为肝糖异生提供乳酸，并且在食物摄入后也为肝糖原合成提供乳酸。脂肪细胞乳酸产生的调节以及脂肪组织乳酸对生理和病理状态下人体燃油经济性的贡献是本次综述的重点。
Estimates of the quantitative contribution of adipose tissue to whole-body glucose metabolism, previously reported as 1-3%, have been revised to be on the order of 10-30%. These revised estimates come, in part, from a recognition that adipose tissue uses glucose to produce lactate and pyruvate, in addition to CO2 and triglycerides. Lactate production by adipose tissue is modulated in vitro by changes in glucose, insulin, and epinephrine concentrations. In vivo, lactate production is regulated acutely by the animal's nutritional state (fed or fasted) and chronically by the degree of obesity. A strong positive correlation exists between rat fat cell size and relative conversion of glucose to lactate (r = 0.89, P < 0.001). Diabetes is also associated with markedly increased lactate production in adipocytes. Fat cells from obese or diabetic rats (or humans) can metabolize to lactate as much as 50-70% of the glucose taken up. From these recent studies, a picture is emerging in which the adipose organ may provide lactate for hepatic gluconeogenesis during fasting, and also lactate for hepatic glycogen synthesis after food ingestion. Modulation of adipocyte lactate production and contribution of adipose tissue lactate to the body's fuel economy in physiological and pathological states are the focus of this review.