Artificial recombination in forensic mtDNA population databases
Artificial recombination in forensic mtDNA population databases
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DOI：
10.1007/s00414-004-0455-2
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发表时间：
2004-10-01
影响因子：
2.1
通讯作者：
Lutz-Bonengel, S
中科院分区：
文献类型：
--
作者：
Bandelt, HJ;Salas, A;Lutz-Bonengel, S
来自不同样品的两个或多个线粒体DNA片段的人工重组将构成法医DNA分型错误的严重原因，然而人们可以证明这样的事件发生在几个已发表的mtDNA数据库的准备中。集中的数据库搜索，系统发育分析和网络表示可以突出马赛克模式，从而查明样本混淆。因此，我们建议，这种方法应适用于数据出版前，以发现这种错误的时间。
Artificial recombination of two or more mitochondrial DNA fragments from different samples would constitute a serious cause of error in forensic DNA typing, and yet one can demonstrate that such events have happened in the preparation of several published mtDNA databases. Focussed database searches, phylogenetic analysis, and network representations can highlight mosaic patterns and thus pinpoint sample mix-up. Therefore, we suggest that this approach should be applied to data prior to publication in order to uncover such errors in time.