Hemodynamic characteristics of sodium-sensitive human subjects.
Hemodynamic characteristics of sodium-sensitive human subjects.
复制标题
对钠敏感的人类受试者的血流动力学特征。
DOI：
10.1161/01.hyp.9.4.398
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Connor,MJ
中科院分区：
文献类型：
--
作者：
Sullivan,JM;Prewitt,RL;Ratts,TE;Josephs,JA;Connor,MJ
58例正常受试者和51例临界高血压受试者在随意饮食、钠耗竭（10 mEq/天）和饱足（200 mEq/天）期间进行微血管和血流动力学研究。血流动力学测量包括动脉血压、心脏指数、总外周阻力、前臂血流量、血管阻力、静脉顺应性和毛细血管滤过分数。微循环的研究包括球结膜的宏观摄影，测量前房、小静脉和毛细血管的密度和直径。在钠补充期间，正常受试者的心脏指数显著增加（2.35 +/- 0.7 vs 2.44 +/- 0.7 L/min/m2; p <0.01），临界高血压受试者的心脏指数显著增加（2.50 +/- 0.7 vs 2.70 +/- 0.8 L/min/m2; p <0.01）。然而，只有33名受试者的平均血压升高超过5%，其中13名正常，20名临界高血压。当这些钠敏感的受试者与血压没有升高的受试者进行比较时，发现前者的前臂血管阻力明显更高（32.2 ± 21 vs 17.9 ± 12 mm Hg/ml/min/100 g; p小于0.01），前臂下段血流（4.42 +/- 2.7 vs 7.47 +/- 5.0 ml/min/100 g）和结膜毛细血管密度较低（3.72 +/- 1.7 vs 5.18 +/- 2.1 [SD] mm/mm 2; p <0.05）。这些结果表明，人体钠敏感性伴随着前臂血管阻力的升高和微循环的衰减。
Fifty-eight normal subjects and 51 subjects with borderline hypertension underwent microvascular and hemodynamic studies while on an ad libitum diet and during periods of sodium depletion (10 mEq/day) and repletion (200 mEq/day). Hemodynamic measurements included arterial blood pressure, cardiac index, total peripheral resistance, forearm blood flow, vascular resistance, venous compliance, and capillary filtration fraction. Studies of the microcirculation consisted of macrophotography of the bulbar conjunctiva with measurement of anteriolar, venular, and capillary density and diameter. During sodium repletion, cardiac index increased significantly in the normal subjects (2.35 +/- 0.7 vs 2.44 +/- 0.7 L/min/m2; p less than 0.01) and in the borderline hypertensive subjects (2.50 +/- 0.7 vs 2.70 +/- 0.8 L/min/m2; p less than 0.01). However, mean blood pressure rose by more than 5% in only 33 subjects, 13 with normal and 20 with borderline hypertension. When these sodium-sensitive subjects were compared with those whose blood pressure did not rise, the former were found to have significantly higher forearm vascular resistance (32.2 +/- 21 vs 17.9 +/- 12 mm Hg/ml/min/100 g; p less than 0.01), lower forearm blood flow (4.42 +/- 2.7 vs 7.47 +/- 5.0 ml/min/100 g) and lower conjunctival capillary density (3.72 +/- 1.7 vs 5.18 +/- 2.1 [SD] mm/mm2; p less than 0.05). These results indicate that sodium sensitivity in humans is accompanied by elevation of forearm vascular resistance and attenuation of the microcirculation.