Age-related pathology and biosenescent markers in captive rhesus macaques
Age-related pathology and biosenescent markers in captive rhesus macaques
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DOI：
10.1007/s11357-997-0001-5
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Uno, H
中科院分区：
文献类型：
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作者：
Uno, H
在过去的15年里，我们的恒河猴种群年龄从20岁到37岁不等，平均每年有88.2只活猴子，其中平均每年有13.9只猴子自发死亡或因严重疾病而被终止。从1980年到1994年，共对175只年龄在20岁到37岁之间的恒河猴进行了尸检。通过累积的尸检数据，调查了各器官年龄相关病理的发生率。10 - 40%的猕猴在20岁后开始出现冠状动脉硬化、肺气肿、退行性关节疾病、癌症、脑淀粉样斑块等主要老年疾病，26岁后发病率显著增加。每年约有12%的20至30岁的老年猕猴死于此类伴有严重并发症的老年疾病。平均存活率表明，20岁人口中有一半在25岁前死亡，73%在30岁前死亡。只有不到10%的猕猴能活过30年。利用这些年老猕猴以及本中心其他幼龄至成年猕猴，进行了临床眼科和生殖内分泌学研究，以及脑磁共振成像（MRI）研究，以确定圈养恒河猴的生物衰老标志物。20%的恒河猴在20至22岁时开始患白内障，26岁后发病率显著上升。绝经发生在26 ~ 27岁。MRI显示老年人多发脑梗死，苍白球及黑质有铁沉积。圈养的老年猕猴的这些老年疾病似乎是自然衰老的结果，因为这些圈养动物的简单生活方式使其受环境因素的影响最小。我们的数据将为年龄相关疾病的预防性或实验性研究提供有用的范例。
During the past 15 years, our aging colony of rhesus monkeys, consisting of animals from 20 to 37 years of age, had an annual average population of 88.2 live monkeys and, of this population, an annual average of 13.9 monkeys died spontaneously or were terminated due to severe illness. From 1980 to 1994, a total of 175 autopsies of rhesus macaques, from 20 to 37 years of age, were performed. By cumulative autopsy data, the incidence of age-related pathology in various organs was surveyed. Major geriatric diseases such as coronary sclerosis, emphysema, degenerative joint disorders, cancer, and cerebral amyloid plaque began to develop in 10 to 40% of macaques after 20 years and the incidence significantly increased after 26 years of age. Approximately 12% of aged macaques from 20 to 30 years of age died annually due to such geriatric diseases with severe complications. The average survival rate indicated that half the population at 20 years of age died by 25 years and 73% died by 30 years of age. Less than 10% of macaques survived over 30 years. Using these aged macaques as well as other juvenile to adult monkeys in our Center, clinical opththalmological and reproductive endocrinological studies, and magnetic resonance imaging (MRI) of the brain were conducted to define bioaging markers of captive rhesus monkeys. Cataracts began to develop in 20% of rhesus monkeys at 20 to 22 years of age and the rate significantly increased after 26 years of age. Menopause occurred at 26 to 27 years of age. Multiple cerebral infarctions and iron deposits in the globus pallidus and substantia nigra were detected by MRI in the aged brains. These geriatric disorders in captive aged macaques appear to be natural aging outcomes, since the simple lifestyle of these captive animals offers minimal exposure to environmental factors. Our data will offer useful paradigms for preventive or experimental studies on age-related diseases.