The Structural Connectome of the Human Central Homeostatic Network
The Structural Connectome of the Human Central Homeostatic Network
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DOI：
10.1089/brain.2015.0378
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发表时间：
2016-04-01
影响因子：
3.4
通讯作者：
Kinney, Hannah C.
中科院分区：
文献类型：
--
作者：
Edlow, Brian L.;McNab, Jennifer A.;Kinney, Hannah C.
对压力的稳态适应受脑干和前脑区域之间的相互作用调节，包括与呼吸、自主、情感和认知处理相关的边缘系统部位。然而，这些自我平衡区域之间的神经解剖学联系在人类大脑中还没有被彻底确定。在这项研究中，我们使用MGH-USC Connectome MRI扫描仪进行弥散谱成像纤维束成像，以可视化人脑中的结构连接，将中脑、脑桥和延髓中的自主神经和心肺神经核与对稳态控制至关重要的前脑部位联系起来。对6名健康成年人的概率纤维束成像分析显示，6个脑干核团与7个前脑区域之间存在联系，其中几个位于尾侧髓质和大脑皮质之间的长距离。在这项研究中，脑干-内稳态前脑连接的最有力证据是脑干中线中缝和内侧颞叶之间。下托和杏仁核是取样的前脑节点与最广泛的脑干连接。在人类脑干内稳态前脑连接体，我们观察到，外侧前脑束，其连接是不同的啮齿动物和非人类灵长类动物，是脑干和内侧颞叶之间的连接的主要管道。这项研究支持的概念，相互连接的脑干和前脑节点形成一个完整的中央稳态网络（CHN）在人类大脑。我们的研究结果提供了一个初步的基础，阐明在正常的人脑内稳态的神经解剖学基础，以及映射CHN断开的内稳态紊乱，包括猝死和意外死亡，癫痫患者。
Homeostatic adaptations to stress are regulated by interactions between the brainstem and regions of the forebrain, including limbic sites related to respiratory, autonomic, affective, and cognitive processing. Neuroanatomic connections between these homeostatic regions, however, have not been thoroughly identified in the human brain. In this study, we perform diffusion spectrum imaging tractography using the MGH-USC Connectome MRI scanner to visualize structural connections in the human brain linking autonomic and cardiorespiratory nuclei in the midbrain, pons, and medulla oblongata with forebrain sites critical to homeostatic control. Probabilistic tractography analyses in six healthy adults revealed connections between six brainstem nuclei and seven forebrain regions, several over long distances between the caudal medulla and cerebral cortex. The strongest evidence for brainstem-homeostatic forebrain connectivity in this study was between the brainstem midline raphe and the medial temporal lobe. The subiculum and amygdala were the sampled forebrain nodes with the most extensive brainstem connections. Within the human brainstem-homeostatic forebrain connectome, we observed that a lateral forebrain bundle, whose connectivity is distinct from that of rodents and nonhuman primates, is the primary conduit for connections between the brainstem and medial temporal lobe. This study supports the concept that interconnected brainstem and forebrain nodes form an integrated central homeostatic network (CHN) in the human brain. Our findings provide an initial foundation for elucidating the neuroanatomic basis of homeostasis in the normal human brain, as well as for mapping CHN disconnections in patients with disorders of homeostasis, including sudden and unexpected death, and epilepsy.