ALCOHOL-CONSUMPTION IN PATIENTS WITH COLORECTAL ADENOMATOUS POLYPS
ALCOHOL-CONSUMPTION IN PATIENTS WITH COLORECTAL ADENOMATOUS POLYPS
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DOI：
10.1136/gut.32.1.70
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发表时间：
1991-01-01
期刊：
影响因子：
24.5
通讯作者：
KELLEHER, J
中科院分区：
文献类型：
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作者：
COPE, GF;WYATT, JI;KELLEHER, J
多种饮食和环境因素可能会增加患结直肠腺瘤性息肉的风险。我们发现与当前的饮酒和吸烟存在关联。不吸烟的饮酒者患息肉的风险增加三倍，不吸烟的吸烟者患息肉的风险增加两倍，同时饮酒和吸烟的人患息肉的风险是完全戒酒者的 12 倍。由于结肠腺瘤性息肉通常被认为是癌前病变，因此这些结果支持了以下观点：饮酒可能是结直肠肿瘤发病机制中的一个重要因素，从而强化了所提出的息肉/癌在结直肠癌发生中的顺序。然而，吸烟的作用尚不清楚，特别是因为许多其他研究都报道结直肠癌与吸烟之间缺乏关联。
The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, with those who both drank and smoked having 12 times the risk of total abstainers. Since colonic adenomatous polyps are generally regarded as premalignant lesions, these results lend support to the view that alcohol consumption may be an important factor in the pathogenesis of colorectal neoplasia, thus reinforcing the proposed polyp/carcinoma sequence in colorectal carcinogenesis. The role of smoking, however, is less clear particularly since the lack of association of colorectal carcinoma and smoking has been reported in many other studies.