Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
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DOI：
10.1016/s0923-2508(00)00169-8
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发表时间：
2000-07-01
影响因子：
2.6
通讯作者：
Alloing, G
中科院分区：
文献类型：
--
作者：
Claverys, JP;Grossiord, B;Alloing, G
肺炎链球菌是一种挑剔的专性寄生虫，需要几种氨基酸才能生长。因此，由Ami ABC渗透酶介导的寡肽摄取对于营养是重要的，但这不能解释Ami突变体所表现出的高度多效性的表型。讨论了肽转运在感知环境条件中起关键作用并间接调节几个基因表达的假设。(C)2000年版《爱思唯尔科学与医学》。
Streptococcus pneumoniae is a fastidious obligate parasite requiring several amino acids for growth. Oligopeptide uptake mediated by the Ami ABC permease is therefore important for nutrition but this could not account for the highly pleiotropic phenotype exhibited by Ami mutants. The hypothesis that peptide transport plays a pivotal role in sensing environmental conditions and indirectly modulates the expression of several genes is discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.