Intestinal epithelium in inflammatory bowel disease.
Intestinal epithelium in inflammatory bowel disease.
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DOI：
10.3389/fmed.2014.00024
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发表时间：
2014
影响因子：
3.9
通讯作者：
Coskun M
中科院分区：
文献类型：
--
作者：
Coskun M
肠上皮细胞具有作为腔微生物群的保护性物理屏障的战略地位，并积极促进粘膜免疫系统。这种屏障主要由单层特化肠上皮细胞（IEC）形成，这些细胞在维持肠道内稳态中至关重要。因此，上皮层内的失调可增加肠道通透性，导致IEC与下层固有层中的免疫细胞之间的相互作用异常，并扰乱肠道免疫稳态，所有这些都与炎症性肠病（IBD）的临床病程相关。了解肠上皮在IBD发病机制中的作用可能有助于提高对炎症过程的认识和识别潜在的治疗靶点。
The intestinal epithelium has a strategic position as a protective physical barrier to luminal microbiota and actively contributes to the mucosal immune system. This barrier is mainly formed by a monolayer of specialized intestinal epithelial cells (IECs) that are crucial in maintaining intestinal homeostasis. Therefore, dysregulation within the epithelial layer can increase intestinal permeability, lead to abnormalities in interactions between IECs and immune cells in underlying lamina propria, and disturb the intestinal immune homeostasis, all of which are linked to the clinical disease course of inflammatory bowel disease (IBD). Understanding the role of the intestinal epithelium in IBD pathogenesis might contribute to an improved knowledge of the inflammatory processes and the identification of potential therapeutic targets.