MRI of pharyngeal airway in children with sleep-disordered breathing.
MRI of pharyngeal airway in children with sleep-disordered breathing.
复制标题
睡眠呼吸障碍儿童的咽部气道 MRI。
DOI：
10.1152/japplphysiol.00832.2005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Quan,StuartF
中科院分区：
文献类型：
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作者：
Fregosi,RalphF;Quan,StuartF
题名/责任者：A.睡眠呼吸障碍儿童高频吸气音的上呼吸道共振器模型。应用生理学杂志99：1855-1861,2005。2004年12月23日首次出版；DOI：10.1152/japplPhysiol。01231.2004.-这项研究的目标是确定患有阻塞性睡眠呼吸障碍的睡眠儿童是如何产生高频吸气声的。我们假设HFIS是在由狭窄的上呼吸道产生的高速气流诱导上呼吸道充当共振室时产生的。我们检验了这一假设的两个预测：1)患有HFIS的儿童上呼吸道狭窄；2)根据HFIS谐波间隔计算的上呼吸道长度与通过磁共振成像(MRI)扫描计算的长度相似。这项研究是在一个睡眠实验室的环境中进行的。参与者包括29名6至12岁的疑似OSDB的儿童，患有扁桃体肥大。用磁共振成像测量清醒儿童的最小气道横截面面积和气道长径(嘴唇到喉部或软腭部)。当天晚上晚些时候，孩子们接受多导睡眠监测时，床上悬挂的麦克风记录了声音。后来用快速傅立叶变换对声音进行了分析。我们发现，与没有发生HFIS的儿童相比，发生HFIS的睡眠儿童的上呼吸道明显狭窄[最小呼吸道面积分别为20.5 4.4 mm2和70.9 22.5 mm2(平均SE)；P 0.02]。最窄气道面积的对数10与每小时记录的HFI数呈显著负相关(R20.55，P 0.00001)。HFIS的谐波特征预测它们是在长为12.0~0.9 cm的腔室中产生的，与MRI测量的从嘴唇到喉部的距离12.8~0.4 cm相似。总而言之，这些数据表明，儿童在以下情况下会发生HFIS：1)他们的上呼吸道狭窄，2)他们的上呼吸道充当共振室。
Rembold, Christopher M., and Paul M. Suratt. An upper airway resonator model of high-frequency inspiratory sounds in children with sleep-disordered breathing. J Appl Physiol 99: 1855–1861, 2005. First published December 23, 2004; doi: 10.1152/japplphysiol. 01231.2004.—The goal of this study was to determine how high-frequency inspiratory sounds (HFIS) are generated by sleeping children with obstructive sleep-disordered breathing (OSDB). We hypothesized that HFIS are generated when a high-velocity jet of air, generated by a narrowed upper airway, induces the upper airway to act as a resonating chamber. We tested two predictions of this hypothesis: 1) the upper airway is narrowed in children who make HFIS and 2) the length of the upper airway, calculated from HFIS harmonic intervals, is similar to that calculated from magnetic resonance imaging (MRI) scans. The study was conducted in the setting of a sleep laboratory. Participants included 29 children between 6 and 12 yr of age with adenotonsillar hypertrophy suspected of having OSDB. Minimum cross-sectional airway area and airway long dimensions (lips to larynx or soft palate) were measured in awake children with MRIs. Later that night, sound was recorded with a microphone suspended above their bed while the children underwent polysomnography. Sounds were later analyzed with fast Fourier transforms. We found that sleeping children who generated HFIS had significantly narrower upper airways compared with children who did not make HFIS [minimum airway area 20.5 4.4 vs. 70.9 22.5 mm2 (mean SE), respectively; P 0.02]. There was a significant inverse correlation between the log10 of the narrowest airway area and the number of HFIS recorded per hour (r2 0.55, P 0.00001). The harmonics characteristics of HFIS predicted that they were generated by sound resonating in chamber whose length was 12.0 0.9 cm, which is similar to the MRI measured distance from the lips to the larynx of 12.8 0.4 cm. In conclusion, these data suggest that children generate HFIS when 1) they have a narrowed upper airway and 2) their upper airway acts as a resonating chamber.