RBM3, A NOVEL HUMAN GENE IN XP11.23 WITH A PUTATIVE RNA-BINDING DOMAIN
RBM3, A NOVEL HUMAN GENE IN XP11.23 WITH A PUTATIVE RNA-BINDING DOMAIN
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DOI：
10.1093/hmg/4.12.2307
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发表时间：
1995-12-01
影响因子：
3.5
通讯作者：
FRANCKE, U
中科院分区：
文献类型：
--
作者：
DERRY, JMJ;KERNS, JA;FRANCKE, U
利用cDNA选择的一个YAC Xp11.2地区,我们发现了一个新基因(RBM3)编码多肽序列相似性高的一组蛋白质与RNA结合,在一个YAC叠连群地图,RBM3位于OATL1之间和GATA1 /副环带Xp11.23 TFE3,和产生或者拼接记录各种人体组织,最长的开放阅读框编码157个氨基酸蛋白质的预测分子量17 kDa,其假定的RNA结合结构域与先前鉴定的两种人类RNA结合蛋白最为相似，即与无精子症有关的基因YRRM和也被鉴定为自身抗原的糖蛋白hnRNP G。RBM3在序列和大小上与玉米中的RNA结合蛋白AAIP具有同源性，这表明它在从植物到哺乳动物的基本途径中起作用。
Using cDNA selection with a YAC from the Xp11.2 region, we have identified a novel gene (RBM3) that encodes a polypeptide with high sequence similarity to a group of proteins that bind to RNA, On a YAC contig map, RBM3 is located between OATL1 and GATA1/TFE3 in sub-band Xp11.23, and gives rise to alternatively spliced transcripts in a variety of human tissues, The longest open reading frame encodes a 157 amino acid protein with a predicted molecular weight of 17 kDa, Its putative RNA-binding domain most closely resembles that of two previously characterized human RNA-binding proteins, YRRM, the gene for which has been implicated in azoospermia, and hnRNP G, a glycoprotein, also identified as an autoantigen, The homology of RBM3 in both sequence and size to an RNA binding protein from maize, AAIP, suggests that it functions in a fundamental pathway conserved from plants to mammals.