SHORT-TERM INTRAINDIVIDUAL VARIABILITY IN LIPOPROTEIN MEASUREMENTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
SHORT-TERM INTRAINDIVIDUAL VARIABILITY IN LIPOPROTEIN MEASUREMENTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1093/oxfordjournals.aje.a116572
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发表时间：
1992-11-01
影响因子：
5
通讯作者：
SHEN, YL
中科院分区：
文献类型：
--
作者：
CHAMBLESS, LE;MCMAHON, RP;SHEN, YL
许多流行病学研究都是基于对假定的危险因素与健康结果之间关联的估计，例如脂蛋白的血浆浓度与缺血性心脏病之间的关联。由于风险因素测量的可重复性在一定程度上决定了确定其在人群中的关联性的能力，因此进行了社区动脉粥样硬化风险 (ARIC) 个体内变异性研究，以估计分析物数据中变异的各个组成部分并估计这些测量的可重复性。 1988 年，对来自北卡罗来纳州福赛斯县、明尼苏达州明尼阿波利斯、密西西比州杰克逊和马里兰州华盛顿县的总共 40 名受试者（17 名男性和 23 名女性）进行了研究。每位受试者采集了 3 次空腹血液，每次访问之间间隔 1 至 2 周。估计了人与人之间的变异性、人内的变异性以及处理和测定变异性的贡献。根据这些组成部分，估计了可靠性系数 R，即重复访问时所做的测量之间的相关性。总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和脂蛋白(a)的R大于0.85。载脂蛋白 A-I 的重复性较低 (R = 0.60)。高密度脂蛋白亚组分 2 和 3 的重复性处于中等水平。 ARIC 个体内变异性研究的可靠性系数通常高于其他研究中发现的可靠性系数，这与所研究人群的相对变异性、测量之间的时间间隔以及实验室变异性的差异有关。仅对于载脂蛋白 A-I，研究结果强烈表明需要调整使用这些分析物之一作为自变量的估计中的测量变异性。
Much epidemiologic research is based on estimation of an association between a putative risk factor and a health outcome-for example, plasma concentration of lipoproteins and ischemic heart disease. Since the repeatability of a risk factor measurement determines, in part, the ability to ascertain its association in populations, the Atherosclerosis Risk in Communities (ARIC) Intraindividual Variability Study was conducted to estimate various components of variation in analyte data and to estimate the repeatability of these measurements. A total of 40 subjects (17 males and 23 females) from Forsyth County, North Carolina, Minneapolis, Minnesota, Jackson, Mississippi, and Washington County, Maryland, were studied in 1988. Fasting blood was collected three times from each subject, with a 1- to 2-week interval between each visit. The contributions of between-person variability, within-person variability, and processing and assay variability were estimated. From these components, the reliability coefficient, R, the correlation between measures made at repeat visits, was estimated. R was above 0.85 for total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, and lipoprotein(a). Low repeatability was obtained for apolipoprotein A-I (R = 0.60). High density lipoprotein subfractions 2 and 3 were intermediate in repeatability. Reliability coefficients from the ARIC Intraindividual Variability Study are generally higher than those found in other studies, and this is related to relative variability in populations studied, to the time between measurements, and to differences in laboratory variability. Only for apolipoprotein A-I would the findings strongly suggest the need to adjust for measurement variability in estimation using one of these analytes as an independent variable.