Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
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DOI：
10.1073/pnas.0913351107
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发表时间：
2009-12
期刊：
影响因子：
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通讯作者：
T. Suenaga;T. Satoh;P. Somboonthum;Y. Kawaguchi;Y. Mori;H. Arase
中科院分区：
文献类型：
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作者：
T. Suenaga;T. Satoh;P. Somboonthum;Y. Kawaguchi;Y. Mori;H. Arase
水痘-带状疱疹病毒（VZV）和单纯疱疹病毒（HSV）是引起多种神经系统疾病的流行性嗜神经疱疹病毒。与其他包膜病毒类似，膜融合是病毒进入的必要过程。因此，鉴定介导膜融合的宿主分子对于理解病毒感染的机制是重要的。在这里，我们证明，髓鞘相关糖蛋白（MAG），主要分布在神经组织，与VZV糖蛋白B（gB）和促进细胞融合时，共表达VZV gB和gH/gL。VZV优先感染MAG转染的少突胶质细胞。MAG还与HSV-1 gB和增强HSV-1感染早幼粒细胞有关。这些结果表明MAG参与了VZV和HSV对神经组织的感染。
Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic herpesviruses that cause various nervous system diseases. Similar to other enveloped viruses, membrane fusion is an essential process for viral entry. Therefore, identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH/gL. VZV preferentially infected MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues.