A HUMAN 9-20 RECIPROCAL TRANSLOCATION ASSOCIATED WITH MALE-INFERTILITY ANALYZED AT PROPHASE AND METAPHASE-I OF MEIOSIS
A HUMAN 9-20 RECIPROCAL TRANSLOCATION ASSOCIATED WITH MALE-INFERTILITY ANALYZED AT PROPHASE AND METAPHASE-I OF MEIOSIS
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DOI：
10.1159/000132219
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
HARGREAVE, TB
中科院分区：
文献类型：
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作者：
CHANDLEY, AC;SPEED, RM;HARGREAVE, TB
详细介绍了通过扩散进行的减数分裂前期分析，该分析是在生育能力低下、少精子的雄性中确定的人类 9;20 相互易位。风干的减数分裂制剂显示在中期 I 存在易位四价体。生殖细胞退化从减数分裂的早期前期开始就很明显。仅在 20% 的细胞中观察到粗线期易位四价和 XY 二价之间的关联，并且似乎不是生殖细胞失败的主要原因。在总共 87% 的分析的所有细胞中观察到粗线期易位断点周围的配对中断和/或粗线期杂交的一只臂中的配对失败。这可能对生殖细胞闭锁有重大影响。
Details are given of a meiotic prophase analysis, carried out by spreading, of a human 9;20 reciprocal translocation ascertained in a subfertile, oligospermic male. Air-dried meiotic preparations revealed the presence of translocation quadrivalents at metaphase I. Germ-cell degeneration was evident from the early prophase of meiosis onward. Associations between the translocation quadrivalent and XY bivalent at pachytene were seen in only 20% of the cells and seemed not to be the prime cause of germ-cell failure. Pairing disruption around the breakpoints of the translocation at pachytene and/or pairing failure in one arm of the pachytene cross was observed in a total of 87% of all cells analyzed. This could have contributed significantly to germ-cell atresia.