Elevated troponin predicts long-term adverse cardiovascular outcomes in hypertensive crisis: a retrospective study
Elevated troponin predicts long-term adverse cardiovascular outcomes in hypertensive crisis: a retrospective study
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DOI：
10.1097/hjh.0b013e3283599b4f
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发表时间：
2012-12-01
影响因子：
4.9
通讯作者：
Pillai, Dilip P.
中科院分区：
文献类型：
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作者：
Pattanshetty, Deepak J.;Bhat, Pradeep K.;Pillai, Dilip P.
背景：高血压危象与不良临床结局相关。高血压危象中常见的肌钙蛋白升高可能归因于心肌供需不匹配或阻塞性冠状动脉疾病（CAD）。然而，在高血压危象和肌钙蛋白升高的患者中，CAD的患病率和长期不良心血管结局尚不清楚。目的：我们试图评估肌钙蛋白升高对心血管结局的影响，并评估肌钙蛋白作为高血压危象患者阻塞性CAD的预测因子的作用。方法：回顾性筛选出现高血压危象的患者（n = 236）。使用电子患者记录获得基线和随访数据，包括事件发生率。排除未进行心肌肌钙蛋白I（cTnI）测定的受试者（n = 65）。其余171例患者中，cTnI升高（cTnI ≥ 0.12 ng/ml）（n = 56）与cTnI正常（cTnI正常
Background: Hypertensive crisis is associated with poor clinical outcomes. Elevated troponin, frequently observed in hypertensive crisis, may be attributed to myocardial supply-demand mismatch or obstructive coronary artery disease (CAD). However, in patients presenting with hypertensive crisis and an elevated troponin, the prevalence of CAD and the long-term adverse cardiovascular outcomes are unknown.Objective: We sought to assess the impact of elevated troponin on cardiovascular outcomes and evaluate the role of troponin as a predictor of obstructive CAD in patients with hypertensive crisis.Methods: Patients who presented with hypertensive crisis (n = 236) were screened retrospectively. Baseline and follow-up data including the event rates were obtained using electronic patient records. Those without an assay for cardiac Troponin I (cTnI) (n = 65) were excluded. Of the remaining 171 patients, those with elevated cTnI (cTnI >= 0.12 ng/ml) (n = 56) were compared with those with normal cTnI (cTnI