Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
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脑出血引起的肠道菌群失调会加剧小鼠的神经炎症
DOI：
10.3389/fmicb.2021.647304
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发表时间：
2021
影响因子：
5.2
通讯作者：
Fu X
中科院分区：
文献类型：
--
作者：
Yu X;Zhou G;Shao B;Zhou H;Xu C;Yan F;Wang L;Chen G;Li J;Fu X
脑出血（ICH）诱导强烈的血肿相关神经炎症反应，改变外周免疫稳态。最近的研究发现，肠道微生物群通过调节免疫稳态和神经炎症在神经变性和自身免疫性疾病中发挥作用。因此，我们研究了血肿诱导的急性脑损伤后ICH、微生物群改变和免疫反应之间的关系。在我们的研究中，我们使用了ICH的小鼠模型，16S核糖体RNA测序表明ICH导致肠道微生物群失调，这反过来又通过免疫介导的机制影响ICH的结果。在ICH引起的生态失调中，存在显著的物种多样性减少和微生物群过度生长，这可能降低肠道运动性并增加肠道通透性。此外，用正常健康微生物群对ICH小鼠进行去离子化可改善ICH后的功能缺陷和神经炎症。同时，细胞追踪研究已经证实了ICH后肠淋巴细胞向脑的迁移。此外，粪便微生物群的治疗性移植可以改善肠道屏障损伤。这些结果支持以下结论：肠道微生物组是ICH诱导的全身性改变的靶点，并被认为对ICH结局具有实质性影响。
Intracerebral hemorrhage (ICH) induces a strong hematoma-related neuroinflammatory reaction and alters peripheral immune homeostasis. Recent research has found that gut microbiota plays a role in neurodegeneration and autoimmune diseases by regulating immune homeostasis and neuroinflammation. Therefore, we investigated the relationship between ICH, microbiota alteration, and immune responses after hematoma-induced acute brain injury. In our study, we used a mouse model of ICH, and 16S ribosomal RNA sequencing showed that ICH causes gut microbiota dysbiosis, which in turn affects ICH outcome through immune-mediated mechanisms. There was prominent reduced species diversity and microbiota overgrowth in the dysbiosis induced by ICH, which may reduce intestinal motility and increase gut permeability. In addition, recolonizing ICH mice with a normal health microbiota ameliorates functional deficits and neuroinflammation after ICH. Meanwhile, cell-tracking studies have demonstrated the migration of intestinal lymphocytes to the brain after ICH. In addition, therapeutic transplantation of fecal microbiota improves intestinal barrier damage. These results support the conclusion that the gut microbiome is a target of ICH-induced systemic alteration and is considered to have a substantial impact on ICH outcome.
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影响因子：
5.4
作者：
Cheng, Yijun;Zan, Jieyu;Zhao, Weiguo
通讯作者：
Zhao, Weiguo
影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
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影响因子：
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作者：
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Scimone, Concetta
影响因子：
1.2
作者：
Vilz, Tim O.;Overhaus, Marcus;Wehner, Sven
通讯作者：
Wehner, Sven
影响因子：
7.3
作者：
Shichita T;Sakaguchi R;Suzuki M;Yoshimura A
通讯作者：
Yoshimura A