Briarane Diterpenes Diminish COX-2 Expression in Human Colon Adenocarcinoma Cells
Briarane Diterpenes Diminish COX-2 Expression in Human Colon Adenocarcinoma Cells
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DOI：
10.1021/np100775a
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发表时间：
2011-04-01
影响因子：
5.1
通讯作者：
Cichewicz, Robert H.
中科院分区：
文献类型：
--
作者：
Joyner, P. Matthew;Waters, Amanda L.;Cichewicz, Robert H.
一种软珊瑚（Briareum sp.）的研究从瓦努阿图分离出三种新的石鳖类，命名为brialalepolidei A（1），B（2）和C（3）。化合物2和3降低人结肠腺癌细胞以及鼠巨噬细胞中考克斯-2的表达。这是有意义的，因为考克斯-2的代谢产物与结肠癌和其它疾病的发病机制有关。
Exploration of a soft Coral (Briareum sp.) from Vanuatu led to the isolation Of three new briaranes, designated brialalepolidei A(1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 inhuman colon adenocarcinoma cells, as Well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.