Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors.
Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors.
复制标题
溶血磷脂酸刺激 PC12 细胞释放神经递质：溶血磷脂酸受体的参与。
DOI：
--
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
T. Inagami
中科院分区：
文献类型：
--
作者：
S. Shiono;K. Kawamoto;N. Yoshida;T. Kondo;T. Inagami
磷脂酶 D 在代谢调节中的重要性正在得到认识。磷脂酶D作用的产物是磷脂酸和溶血磷脂酸(LPA)。这些脂质产物是否通过质膜受体介导的机制发挥作用尚不清楚。在本研究中，我们发现 PC12 嗜铬细胞瘤细胞的质膜中存在 LPA 特异性受体。 LPA 引起 [Ca2+]i 短暂升高，同时形成 IP3。 LPA 还刺激 PC12 细胞释放多巴胺。这些结果表明，LPA 可能通过激活 IP3 介导的 Ca2+ 释放，通过特定的 LPA 受体刺激儿茶酚胺释放。
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear. In the present study we have shown the presence of specific receptors for LPA in plasma membranes of PC12 pheochromocytoma cells. LPA evoked a transient rise in [Ca2+]i concomitant with formation of IP3. LPA also stimulated dopamine release from PC12 cells. These results indicate that LPA stimulates catecholamine release via specific LPA receptors presumably by activating the IP3 mediated Ca2+ release.