Outcomes of pregnancies complicated by hyperemesis gravidarum
Outcomes of pregnancies complicated by hyperemesis gravidarum
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DOI：
10.1097/01.aog.0000195060.22832.cd
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发表时间：
2006-02-01
影响因子：
7.2
通讯作者：
Butler, Blair
中科院分区：
文献类型：
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作者：
Dodds, Linda;Fell, Deshayne B.;Butler, Blair
目的：为了评估产妇和新生儿的结果与妊娠期剧吐的妇女在pregnancy.METHODS：人口为基础的回顾性队列研究进行了1988年和2002年之间的单胎分娩的妇女。妊娠24周前因剧吐需要一次或多次产前入院的孕妇定义为妊娠剧吐。根据产前住院次数（1或2次vs 3次或以上）和妊娠期间体重增加（< 7 kg [15.4 lb] vs>= 7 kg）评估剧吐的严重程度。评价的母体结局包括妊娠期体重增加、妊娠期糖尿病、妊娠期高血压、引产和剖宫产。新生儿结局包括5分钟Apgar评分小于7分、低出生体重、小于胎龄儿、早产和围产儿死亡。Logistic回归用于产生所有结局的调整优势比，优势比转换为相对risk.Results：在156，091例单胎妊娠中，1，270例因剧吐入院。与无剧吐的女性相比，妊娠期体重增加低（< 7 kg [15.4 Ib]）的女性所生婴儿更可能是低出生体重、小于胎龄儿（SGA）、在妊娠37周前出生、5分钟Apgar评分小于7。与无剧吐的妇女所生婴儿相比，有剧吐和妊娠增重低的妇女所生婴儿的低出生体重和早产率显著较高（分别为4.2%和12.5%，4.9%和13.9%）。妊娠期体重增加7公斤（15.4磅）或以上的妇女与剧吐的婴儿出生的结果没有不同的妇女之间的结果没有hyperemission.CONCLUSION：本研究的结果表明，与剧吐的不良婴儿的结果是一个后果，大多数局限于产妇体重增加不佳的妇女。
OBJECTIVE: To evaluate maternal and neonatal outcomes among women with hyperemesis during pregnancy.METHODS: A population-based retrospective cohort study was conducted among women with singleton deliveries between 1988 and 2002. Hyperemetic pregnancies were defined as those requiring one or more antepartum admissions for hyperemesis before 24 weeks of gestation. Severity of hyperemesis was evaluated according to the number of antenatal hospital admissions (1 or 2 versus 3 or more) and according to weight gain during pregnancy (< 7 kg [15.4 Ib] versus >= 7 kg). Maternal outcomes evaluated included weight gain during pregnancy, gestational diabetes, gestational hypertension, labor induction, and cesarean delivery. Neonatal outcomes included 5-minute Apgar score of less than 7, low birth weight, small for gestational age, preterm delivery, and perinatal death. Logistic regression was used to generate adjusted odds ratios for all outcomes, and the odds ratios were converted to relative risks.RESULTS: Of the 156,091 singleton pregnancies, 1,270 had an admission for hyperemesis. Compared to women without hyperemesis, infants born to women with hyperemesis and with low pregnancy weight gain (< 7 kg [15.4 Ib]) were more likely to be low birth weight, small for gestational age (SGA), born before 37 weeks of gestation, and have a 5-minute Apgar score of less than 7. Compared with infants born to women without hyperemesis, rates of low birth weight and preterm delivery were substantially higher among infants born to women with hyperemesis and low pregnancy weight gain (4.2% versus 12.5% and 4.9% versus 13.9%, respectively). The outcomes among infants born to women with hyperemesis with pregnancy weight gain of 7 kg (15.4 Ib) or more were not different from the outcomes among women without hyperemesis.CONCLUSION: The results of this study suggest that the adverse infant outcomes associated with hyperemesis are a consequence of, and mostly limited to, women with poor maternal weight gain.