A recurrent network in the lateral amygdala: a mechanism for coincidence detection.
A recurrent network in the lateral amygdala: a mechanism for coincidence detection.
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DOI：
10.3389/neuro.04.003.2008
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发表时间：
2008
影响因子：
3.5
通讯作者：
Doyère V
中科院分区：
文献类型：
--
作者：
Johnson LR;Hou M;Ponce-Alvarez A;Gribelyuk LM;Alphs HH;Albert L;Brown BL;Ledoux JE;Doyère V
杏仁外侧核（LAd）感觉输入的突触变化在联想恐惧记忆的获得和储存中起着关键作用。然而，无论是时间还是空间结构的LAD网络的感觉信号的反应是理解。我们开发了一种用于阐明网络行为的方法。使用这种方法，时间模式的多突触经常性网络反应被发现在左前降支（内LA），在体外和体内，在响应丘脑感觉传入的激活。丘脑传入的增强导致LA内突触活动的抑制，表明LAD网络内突触强度变化的稳态反应。此外，丘脑传入的lavage触发经常性的网络活动内的左前降支重叠与已知的后来发生的皮质传入lavage。因此，这种经常性的网络可能有助于在联想学习过程中LAd内的感觉传入的时间重合。
Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning.