A multiwavelength frequency-domain near-infrared cerebral oximeter.
A multiwavelength frequency-domain near-infrared cerebral oximeter.
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DOI：
10.1088/0031-9155/44/3/015
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发表时间：
1999-03
影响因子：
3.5
通讯作者：
C. Kurth;W. Thayer
中科院分区：
文献类型：
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作者：
C. Kurth;W. Thayer
本研究在人脑的体外模型中测试多波长频域近红外血氧仪（fdNIRS）。该模型是一个固体塑料结构，包含一个血管网络灌注血液，其中血红蛋白氧饱和度（SO2）的测量通过一氧化碳血氧测定法，提供了一个标准进行比较。还添加了不同厚度（0.5-2 cm）的塑料壳，其自身具有血管网络并环绕大脑模型，以模拟婴儿、儿童和成人的颅外组织。fdNIRS血氧计利用频域技术监测754 nm、785 nm和816 nm处相对于780 nm参考的相移，以通过光子传输和Beer-Lambert方程推导SO2。我们发现fdNIRS SO2和一氧化碳血氧测定法SO2之间具有良好的线性关系（r2 >或= 0.95），符合所有实验（n = 7）中的同一性线。fdNIRS血氧测定的偏倚为-2%，精密度为6%。血液温度和fdNIRS源-检测器距离不影响fdNIRS血氧测定。低血红蛋白浓度（6 g dl（-1））改变了fdNIRS与一氧化碳血氧测定法的直线斜率和截距，在SO2极值处产生15%的误差。覆盖在大脑模型上的婴儿和儿童样外壳没有改变fdNIRS血氧测定，而成人样外壳产生的误差高达32%。总之，fdNIRS在体外脑模型中准确测量SO2，尽管低血红蛋白浓度和成人厚度的颅外组织影响准确性。
This study tests a multiwavelength frequency-domain near-infrared oximeter (fdNIRS) in an in vitro model of the human brain. The model is a solid plastic structure containing a vascular network perfused with blood in which haemoglobin oxygen saturation (SO2) was measured by co-oximetry, providing a standard for comparison. Plastic shells of varying thickness (0.5-2 cm), with a vascular network of their own and encircling the brain model, were also added to simulate extracranial tissues of the infant, child and adult. The fdNIRS oximeter utilizes frequency-domain technology to monitor phaseshifts at 754 nm, 785 nm and 816 nm relative to a 780 nm reference to derive SO2 through photon transport and Beer-Lambert equations. We found a linear relationship between fdNIRS SO2 and co-oximetry SO2 with excellent correlation (r2 > or = 0.95) that fitted the line of identity in all experiments (n = 7). The bias of fdNIRS oximetry was -2% and the precision was 6%. Blood temperature and fdNIRS source-detector distance did not affect fdNIRS oximetry. Low haemoglobin concentration (6 g dl(-1)) altered the fdNIRS versus co-oximetry line slope and intercept, producing a 15% error at the extremes of SO2. The infant- and child-like shells overlying the brain model did not alter fdNIRS oximetry, whereas the adult-like shell yielded an error as high as 32%. In conclusion, fdNIRS accurately measures SO2 in an in vitro brain model, although low haemoglobin concentration and extracranial tissue of adult thickness influence accuracy.