Collision cross section measurements for biomolecules within a high-resolution FT-ICR cell: theory.
Collision cross section measurements for biomolecules within a high-resolution FT-ICR cell: theory.
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DOI：
10.1039/c4cp06065b
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Dan Guo;Yi Xin;Dayu Li;W. Xu
中科院分区：
文献类型：
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作者：
Dan Guo;Yi Xin;Dayu Li;W. Xu
提出了一个含能硬球离子-中性粒子碰撞模型，利用高分辨率傅里叶变换离子回旋共振（FT-ICR）池中的镜像电流，对离子碰撞截面（CCS）进行了桥接计算.通过研究高阶电场和镜像电荷力引起的非线性效应，对高能硬球碰撞模型进行了实验验证。讨论了含能硬球碰撞模型以及传统的Langevin模型和硬球碰撞模型的适用范围。本文应用含能硬球碰撞模型从高分辨FT-ICR质谱中提取离子CCSs。在本研究中的讨论也适用于FT-轨道和FT-四极离子阱。
In this study, an energetic hard-sphere ion-neutral collision model was proposed to bridge-link ion collision cross section (CCS) with the image current collected from a high-resolution Fourier transform ion cyclotron resonance (FT-ICR) cell. By investigating the nonlinear effects induced by high-order electric fields and image charge forces, the energetic hard-sphere collision model was validated through experiments. Suitable application regions for the energetic hard-sphere collision model, as well as for the conventional Langevin and hard-sphere collision models, were also discussed. The energetic hard-sphere collision model was applied in the extraction of ion CCSs from high-resolution FT-ICR mass spectra. Discussions in the present study also apply to FT-Orbitraps and FT-quadrupole ion traps.