Effect of progabide on serum phenytoin and carbamazepine concentrations.

Effect of progabide on serum phenytoin and carbamazepine concentrations.
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丙加必特对血清苯妥英和卡马西平浓度的影响。

DOI:
10.1097/00002826-198712000-00006
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发表时间:
1987
影响因子:
1
通讯作者:
Welty,TE
Welty,TE
中科院分区:
医学4区
文献类型:
--
作者:
Brundage,RC;Cloyd,JC;Leppik,IE;Graves,NM;Welty,TE

文献摘要

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Progabide (PGB) is a [gamma]-aminobutyric acid (GABA)-agonist drug undergoing clinical evaluation for the treatment of spasticity, movement disorders, and epilepsy. Drug interactions were studied during a randomized, double-blind, crossover trial of the efficacy and toxicity of PGB in patients with partial seizures taking phenytoin (PHT) and carbamazepine (CBZ).