Cytology of metastatic cutaneous melanoma to the vitreous and retina.
Cytology of metastatic cutaneous melanoma to the vitreous and retina.
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玻璃体和视网膜转移性皮肤黑色素瘤的细胞学。
DOI：
10.1097/00006982-199616040-00009
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Grossniklaus,HE
中科院分区：
文献类型：
--
作者：
Spraul,CW;Martin,DF;Hagler,WS;Grossniklaus,HE
目的：作者报告1例确诊和1例假定转移性皮肤恶性黑色素瘤的玻璃体和视网膜诊断的玻璃体和视网膜下fluid.Methods细胞学评价：诊断性玻璃体切除术与不典型的玻璃体和视网膜浸润。此外，从第二名患者中获得视网膜下液。对标本进行细胞学检查。细胞学标本进行了比较，以前切除的皮肤黑色素瘤的患者。结果如下：检查结果显示玻璃体中的细胞具有高核质比、粗染色质和胞浆内黑色素颗粒。细胞学特征与皮肤恶性黑色素瘤进行比较，并作出转移性黑色素瘤的诊断。一名患者最终需要眼球摘除术，另一名患者的转移性肿瘤通过局部照射得到控制。结论：玻璃体和视网膜下液的细胞学评价有助于对转移到玻璃体和视网膜的皮肤黑色素瘤患者进行诊断。视网膜16：328-332，1996
Purpose: The authors report one patient with definitive and one patient with presumed metastatic cutaneous malignant melanoma to the vitreous and retina diagnosed by cytologic evaluation of the vitreous and Subretinal fluid.Methods: A diagnostic vitrectomy was performed on two patients with atypical vitreous and retinal infiltrates. Additionally, subretinal fluid was obtained from the second patient. The specimens were processed for cytologic examination. The cytology specimens were compared with previously excised cutaneous melanomas from the patients. Results: Examination results showed cells in the vitreous with high nuclear-to-cytoplasm ratios, coarse chromatin, and intracytoplasmic melanin pigment granules. The cytologic features were compared with the cutaneous malignant melanoma, and a diagnosis of metastatic melanoma was made. One patient eventually required enucleation, and the metastatic tumor in the other patient was controlled by local irradiation. Conclusions: Cytologic evaluation of the vitreous and subretinal fluid is helpful in establish-ing a diagnosis in patients with metastatic cutaneous melanoma to the vitreous and retina. RETINA 16: 328–332, 1996