Relationship of limb length inequality with radiographic knee and hip osteoarthritis
Relationship of limb length inequality with radiographic knee and hip osteoarthritis
复制标题
DOI：
10.1016/j.joca.2007.01.009
复制
发表时间：
2007-07-01
影响因子：
7
通讯作者：
Jordan, J. M.
中科院分区：
文献类型：
--
作者：
Golightly, Y. M.;Allen, K. D.;Jordan, J. M.
目的：本研究在一个大型的社区样本中检测了肢体长度不等（LLI）与影像学髋关节和膝关节骨关节炎（OA）的关系。方法：总研究组包括926名影像学膝关节OA参与者，796名影像学髋关节OA参与者，210名（6.6%）LLI >2 cm参与者。影像学CA的存在被定义为Kellgren/Lawrence（K/L）分级≥ 2。在控制年龄、性别、种族、体重指数和髋关节或膝关节疾病史的情况下，使用多元逻辑回归模型来检查LLI与髋关节和膝关节OA的关系（关节损伤、骨折、手术或先天性畸形）。结果：在未校正的分析中，LLI受试者比无LLI受试者更有可能发生放射学膝关节OA（45.1%vs28.3%，P < 0.001）和X线髋关节CA（35.2%vs28.7%，P = 0.063）。在多元逻辑回归模型中，膝关节CA与LLI的存在显著相关（调整后的比值比[aOR] = 1.80，95%置信区间[95% CI] 1.29-2.52），但髋关节OA与LLI之间无显著相关性（aOR = 1.20，95% CI 0.86-1.67）。在LLI患者中，当对侧肢体较长时，右侧髋关节OA更常见（30.3%比17.5%，P= 0.070）。结论：LLI与放射学膝关节OA相关，控制了其他重要变量。未来的研究应该检查LLI与髋关节或膝关节CA发病率、进展和症状严重程度的关系，以及LLI矫正治疗OA的疗效。(c)2007年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: This study examined the relationship of limb length inequality (LLI) with radiographic hip and knee osteoarthritis (OA) in a large, community-based sample.Methods: The total study group comprised 926 participants with radiographic knee OA, 796 with radiographic hip OA, and 210 (6.6%) with LLI >2 cm. The presence of radiographic CA was defined as Kellgren/Lawrence (K/L) grade >= 2. Multiple logistic regression models were used to examine the relationship of LLI with hip and knee OA, while controlling for age, gender, race, body mass index, and history of hip or knee problems (joint injury, fracture, surgery, or congenital anomalies).Results: In unadjusted analyses, participants with LLI were more likely than those without LLI to have radiographic knee OA (45.1 % vs 28.3%, P < 0.001) and radiographic hip CA (35.2% vs 28.7%, P = 0.063). In multiple logistic regression models, knee CA was significantly associated with presence of LLI (adjusted Odds Ratio [aOR] = 1.80, 95% Confidence Interval [95% CI] 1.29-2.52), but there was no significant relationship between hip OA and LLI (aOR = 1.20, 95% Cl 0.86-1.67). Among participants with LLI, right hip OA was more common when the contralateral limb was longer than when the ipsilateral limb was longer (30.3% vs 17.5%, P= 0.070).Conclusion: LLI was associated with radiographic knee OA, controlling for other important variables. Future research should examine the relationship of LLI with hip or knee CA incidence, progression, and symptom severity, as well as the efficacy for LLI corrective treatments in OA. (c) 2007 Ostecarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.