Severe interstitial pneumonia associated with anti-PD-1 immune checkpoint antibody after talc slurry pleurodesis
Severe interstitial pneumonia associated with anti-PD-1 immune checkpoint antibody after talc slurry pleurodesis
复制标题
DOI：
10.1016/j.resinv.2017.11.006
复制
发表时间：
2018-03-01
影响因子：
3.1
通讯作者：
Nakayama, Hideki
中科院分区：
文献类型：
--
作者：
Sakata, Shinya;Matsuoka, Yuichiro;Nakayama, Hideki
一例70岁的日本男性头颈部复发性鳞状细胞癌患者在滑石粉浆胸膜固定术后出现与纳武利尤单抗相关的重度间质性肺炎。恶性胸腔积液发生后，患者接受胸腔引流，并在胸腔内给予滑石粉作为胸膜固定术。两周后，我们给予纳武单抗（3 mg/kg），每2周重复一次。然而，在第12天，胸部计算机断层扫描显示弥漫性非节段性毛玻璃样阴影和轻度支气管扩张。我们诊断为与纳武单抗相关的间质性肺炎。尽管开始皮质类固醇冲击治疗，但患者在第14天死于呼吸衰竭。(C)2017年日本呼吸学会。Elsevier B. V.出版，保留所有权利。
A 70-year-old Japanese man with recurrent squamous cell carcinoma of the head and neck presented with severe interstitial pneumonia associated with nivolumab, after talc slurry pleurodesis. Following the development of malignant pleural effusion, he underwent chest drainage and was administered intrathoracic talc as a pleurodesis. Two weeks later, we administered nivolumab (3 mg/kg) to be repeated every 2 weeks. However, on day 12, chest computed tomography scan demonstrated diffuse non-segmental ground-glass opacity and mild bronchiectasis. We diagnosed interstitial pneumonia associated with nivolumab. Although corticosteroid pulse therapy was initiated, the patient died of respiratory failure on day 14. (C) 2017 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.