Clinical value of [18-F] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas
Clinical value of [18-F] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas
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DOI：
10.1097/00000658-200003000-00011
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发表时间：
2000-03-01
影响因子：
9
通讯作者：
Herfarth, C
中科院分区：
文献类型：
--
作者：
Schwarzbach, MHM;Dimitrakopoulou-Strauss, A;Herfarth, C
目的评价正电子发射断层扫描（PET）2-氟-2-脱氧-D-葡萄糖（FDG）在软组织肉瘤中的临床应用价值。都是预先收集的计算肿瘤和正常组织（肌肉）的半定量FDG摄取（标准化摄取值[SUV]）。手术标本的组织学和随访数据作为对照criteris.ResultsIn原发性软组织肉瘤，PET显示的敏感性为91%，特异性为88%。诊断局部复发的敏感性为88%，特异性为92%。所有中、高级别软组织肉瘤（原发性和局部复发性）均与肌肉有明确的鉴别，50%的低级别软组织肉瘤显示与肌肉相当的FDG摄取（1例原发性和3例复发性软组织肉瘤假阴性）。良性软组织肿瘤（例如，脂肪瘤、平滑肌瘤、神经节瘤）不蓄积FDG。炎症导致FDG摄取增加。FDG半定量摄取（SUVs）与肿瘤分级相关，但与肿瘤大小和组织学类型无关。结论高、中级别软组织肉瘤适合PET显像，而低级别病变可能无法显示，FDG半定量摄取与肿瘤分级相关，良性软组织肿瘤与高级别软组织肉瘤相鉴别。这些数据表明FDG-PET可以补充软组织肉瘤的术前放射学评估，并且FDG-PET是检测高级别和中等级别局部复发的有力诊断工具。
ObjectiveTo evaluate positron emission tomography (PET) using 2-fluoro-2-deoxy-D-glucose (FDG) for clinical application in soft tissue sarcomas.Summary and Background DataFDG PET is a promising noninvasive method for the preoperative assessment of soft tissue sarcomas and may complement radiologic tomography.MethodsData from 50 consecutive patients with 59 masses, either suspicious for primary or locally recurrent soft tissue sarcoma, were prospectively gathered. The semiquantitative FDG uptake (standardized uptake values [SUVs]) was calculated in tumor and normal tissue (muscle). Histopathology of surgical specimens and follow-up data were used as control criteria.ResultsIn primary soft tissue sarcomas, PET displayed a sensitivity of 91% and a specificity of 88%. Local recurrence was detected with a sensitivity of 88% and a specificity of 92%, All intermediate-grade and high-grade soft tissue sarcomas (primary and locally recurrent) were Visualized with a precise differentiation from muscle, Fifty percent of the low-grade sarcomas showed an FDG uptake equivalent to muscle (false-negative results in one primary and three recurrent soft tissue sarcomas). Benign soft tissue tumors (e.g., lipoma, leiomyoma, ganglion) did not accumulate FDG. inflammation resulted in an increased FDG uptake. The semiquantitative FDG uptake (SUVs) correlated with tumor grade but not with size and histologic type.ConclusionHigh-grade and intermediate-grade soft tissue sarcomas are amenable to PET imaging, whereas low-grade lesions may not be depicted, SUVs for FDG correlate with tumor grade in soft tissue sarcomas, Benign soft tissue tumors are differentiated from higher-grade soft tissue sarcomas. These data show that FDG-PET can complement preoperative radiologic assessment for soft tissue sarcomas and that FDG-PET is a powerful diagnostic toot for detecting high-grade and intermediate-grade local recurrence.