An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
复制标题
DOI：
10.1046/j.1365-2567.1997.d01-2281.x
复制
发表时间：
1997-08-01
期刊：
影响因子：
6.4
通讯作者：
Suzuki, S
中科院分区：
文献类型：
--
作者：
Shinomiya, T;Li, XK;Suzuki, S
我们先前报道FTY720是一种有效的淋巴细胞和培养细胞的凋亡诱导剂。台词。在本研究中，HL-60人早幼粒细胞瘤细胞也通过药物体外处理诱导了细胞凋亡，孵育6小时后显示出广泛的DNA片段化。FTY720的主要靶点是细胞凋亡的共同信号通路，因为快速的(
We previously reported that FTY720 is an efficient inducer of apoptosis in lymphocytes and cultured cell. lines. In the present study, HL-60 human promyerocytoma cells also induced apoptosis through in vitro treatment with the drug, demonstrating extensive DNA fragmentation 6 hr after incubation. The major target of FTY720 was the common signalling pathway of apoptosis, since a rapid (