Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis.
Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis.
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DOI：
10.1096/fj.202100067r
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Dasgupta S
中科院分区：
文献类型：
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作者：
Adebayo M;Singh S;Singh AP;Dasgupta S
线粒体是高度动态的、母系遗传的细胞质细胞器，其通过氧化磷酸化系统满足细胞能量需求。此外，它们在钙和损伤相关分子模式（DAMPs）信号传导、氨基酸和脂质代谢以及细胞凋亡中发挥积极作用。因此，维持线粒体的完整性和稳态是极其重要的，这是通过不断的融合和裂变来实现的。线粒体融合允许基因产物在线粒体之间转移以实现最佳功能，特别是在代谢和环境压力下。另一方面，裂变对于线粒体分裂和质量控制至关重要。这两个过程之间的不平衡与各种疾病有关，如癌症，神经退行性疾病和心血管疾病。这篇综述讨论了控制线粒体融合和分裂的分子机制，以及线粒体动力学的破坏如何表现为各种疾病。
Mitochondria are highly dynamic, maternally inherited cytoplasmic organelles, which fulfill cellular energy demand through the oxidative phosphorylation system. Besides, they play an active role in calcium and damage-associated molecular patterns (DAMPs) signaling, amino acid, and lipid metabolism, and apoptosis. Thus, the maintenance of mitochondrial integrity and homeostasis is extremely critical, which is achieved through continual fusion and fission. Mitochondrial fusion allows the transfer of gene products between mitochondria for optimal functioning, especially under metabolic and environmental stress. On the other hand, fission is crucial for mitochondrial division and quality control. The imbalance between these two processes is associated with various ailments such as cancer, neurodegenerative and cardiovascular diseases. This review discusses the molecular mechanisms that control mitochondrial fusion and fission and how the disruption of mitochondrial dynamics manifests into various disease conditions.