Molecular Evidence Supports the Role of Dogs as Potential Reservoirs for Rickettsia felis
Molecular Evidence Supports the Role of Dogs as Potential Reservoirs for Rickettsia felis
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DOI：
10.1089/vbz.2010.0270
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发表时间：
2011-08-01
影响因子：
2.1
通讯作者：
Traub, Rebecca J.
中科院分区：
文献类型：
--
作者：
Hii, Sze Fui;Kopp, Steven R.;Traub, Rebecca J.
猫立克次体在世界范围内引起人类跳蚤传播的斑点热。猫蚤（Ctenocephalides felis）是该病原体的媒介和储存宿主。为了确定犬作为斑点热群立克次体潜在储存宿主的作用，我们使用高灵敏度属特异性PCR对昆士兰州东南部100磅犬的血液进行了筛选。其中9磅狗的立克次体DNA呈阳性，随后的分子测序证实了立克次体的扩增。猫R.本研究提示狗可能是R.猫和人类立克次体感染的潜在来源。
Rickettsia felis causes flea-borne spotted fever in humans worldwide. The cat flea, Ctenocephalides felis, serves as vector and reservoir host for this disease agent. To determine the role of dogs as potential reservoir hosts for spotted fever group rickettsiae, we screened blood from 100 pound dogs in Southeast Queensland by using a highly sensitive genus-specific PCR. Nine of the pound dogs were positive for rickettsial DNA and subsequent molecular sequencing confirmed amplification of R. felis. A high prevalence of R. felis in dogs in our study suggests that dogs may act as an important reservoir host for R. felis and as a potential source of human rickettsial infection.