A meta-analysis of receptor for advanced glycation end products gene: Four well-evaluated polymorphisms with diabetes mellitus
A meta-analysis of receptor for advanced glycation end products gene: Four well-evaluated polymorphisms with diabetes mellitus
复制标题
DOI：
10.1016/j.mce.2012.02.010
复制
发表时间：
2012-07-06
影响因子：
4.1
通讯作者：
Jin, Wei
中科院分区：
文献类型：
--
作者：
Niu, Wenquan;Qi, Yue;Jin, Wei
关于晚期糖基化终产物（RAGE）和糖尿病的基因编码受体的遗传关联研究报告了相互矛盾的结果。为了评估 RAGE 基因四种广泛评估的多态性（T-429C、T-374A、Gly82Ser 和 G1704T）与糖尿病的关联，进行了荟萃分析。无论研究之间的异质性如何，都应用随机效应模型。 T-429C 共有 5808/3742 (n = 14) 例病例/对照（研究），T-374A 共有 8259/6935 (n = 19)，Gly82Ser 共有 7029/5266 (n = 19)，Gly82Ser 共有 2843/3302 (n = 13)。 G1704T。总体结果发现，T-429C、T-374A 和 Gly82Ser 多态性与糖尿病风险没有显着关联。相对于 1704G，等位基因 1704T 的风险有增加的趋势（比值比 [OR] = 1.09；95% 置信区间 [CI]：0.98-1.22；I-2 = 0）。按种族进行的亚组分析表明，等位基因 17041 在东亚人中显着增加风险（OR = 1.21；95% CI：1.04-1.4；I-2 = 0），但在白种人中则不然（OR = 0.8；95% CI：0.6-1.07；I-2 = 0），并且按糖尿病类型显示，这种关联仅针对以下人群而增强： G1704T 与 糖尿病视网膜病变（OR = 1.24；95% CI：1.01-1.51；I-2 = 0）。没有观察到发表偏倚。我们的结果提供了令人信服的证据，证明 RAGE 基因 1704T 等位基因与糖尿病（尤其是糖尿病视网膜病变）风险增加之间的关联。值得注意的是，这种效应在东亚人中更为明显。 (c) 2012 Elsevier Ireland Ltd. 保留所有权利。
Genetic association studies on the gene encoding receptor for advanced glycation end products (RAGE) and diabetes mellitus have reported conflicting results. To evaluate the association of RAGE gene four widely-evaluated polymorphisms (T-429C, T-374A, Gly82Ser and G1704T) and diabetes mellitus, a meta-analysis was conducted. A random-effects model was applied irrespective of between-study heterogeneity. There were a total of 5808/3742 (n = 14) case-patients/controls (studies) for T-429C, 8259/6935 (n = 19) for T-374A, 7029/5266 (n = 19) for Gly82Ser, and 2843/3302 (n = 13) for G1704T. Overall results detected no significant association of polymorphisms T-429C, T-374A and Gly82Ser with diabetes risk. There was a trend toward an increased risk for alleles 1704T relative to 1704G (odds ratio [OR] = 1.09; 95% confidence interval [CI]: 0.98-1.22; I-2 = 0). Subgroup analysis by ethnicity indicated that allele 17041 conferred a significantly increased risk in East Asians (OR = 1.21; 95% CI: 1.04-1.4; I-2 = 0) but not in Caucasians (OR = 0.8; 95% CI: 0.6-1.07; I-2 = 0), and that by type of diabetes mellitus indicated that association was potentiated exclusively for G1704T with diabetic retinopathy (OR = 1.24; 95% CI: 1.01-1.51; I-2 = 0). No publication bias was observed. Our results provide convincing evidence regarding the association of RAGE gene 1704T allele with an increased risk of diabetes mellitus, especially diabetic retinopathy. Notably, this effect was more pronounced in East Asians. (c) 2012 Elsevier Ireland Ltd. All rights reserved.