Familial factors confound the association between maternal smoking during pregnancy and young adult offspring overweight
Familial factors confound the association between maternal smoking during pregnancy and young adult offspring overweight
复制标题
DOI：
10.1093/ije/dyq064
复制
发表时间：
2010-10-01
影响因子：
7.7
通讯作者：
Cnattingius, Sven
中科院分区：
文献类型：
--
作者：
Iliadou, Anastasia Nyman;Koupil, Ilona;Cnattingius, Sven
方法在一个以人口为基础的瑞典队列，包括124 203个单身男性出生的北欧母亲在1983年和1988年之间，我们研究了母亲在怀孕期间吸烟和超重的风险在后代的年龄相似的18岁之间的关联。我们还调查了兄弟姐妹之间的关联，控制共同的基因和共享的environment.Results在队列分析中，吸烟母亲的儿子超重的风险增加与非吸烟者的儿子相比：每日吸烟1 ~ 9支和> 10支的校正比值比分别为1.41，95%可信区间（CI）1.34-1.49和1.56，95% CI 1.46-1.66。将母亲的吸烟习惯分为两次男性怀孕，只有当母亲在两次男性怀孕中都吸烟时，第二个儿子超重的风险才会增加。在怀孕期间吸烟对后代的体重指数的影响是不存在的关联进行评估时，在全和半siblingpairs.Conclusion母亲在怀孕期间吸烟和后代的超重的风险之间的关联似乎是混淆的家庭因素。
Methods In a population-based Swedish cohort comprising 124 203 singleton males born to Nordic mothers between 1983 and 1988, we examined the association between maternal smoking during pregnancy and the risk of overweight in the offspring at age similar to 18 years. We also investigated the association within siblings, controlling for common genes and shared environment.Results In the cohort analyses, the risk of overweight was increased in sons of smoking mothers compared with sons of non-smokers: adjusted odds ratios 1.41, 95% confidence interval (CI) 1.34-1.49, and 1.56, 95% CI 1.46-1.66, for one to nine cigarettes per day, and > 10 cigarettes per day, respectively. Stratifying for maternal smoking habits across two subsequent male pregnancies, there was an increased risk of overweight for the second son only if the mother was smoking in both male pregnancies. The effect of smoking during pregnancy on the offspring's body mass index was not present when the association was evaluated within full and half sibling pairs.Conclusion The association between maternal smoking during pregnancy and offspring's risk of overweight appears to be confounded by familial factors.