Epidemiological Study of the Association Between Malaria and Helminth Infections in Nigeria
Epidemiological Study of the Association Between Malaria and Helminth Infections in Nigeria
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DOI：
10.4269/ajtmh.14-0548
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发表时间：
2015-03-01
影响因子：
3.3
通讯作者：
Konig, Brigitte
中科院分区：
文献类型：
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作者：
Efunshile, Aldnwale Michael;Olawale, Temitope;Konig, Brigitte
肠道蠕虫感染与疟疾易感性之间的关系尚不清楚。我们研究了这些感染之间的关系。尼日利亚伊莱罗的七所学校将所有患有发热性疾病的学生转介到我们的研究中心，在为期3个月的研究期间免费治疗疟疾。最后，所有学生都提交了一份粪便样本，以进行蠕虫卵的显微镜检查。我们使用不匹配的病例对照设计来计算在研究期间至少有一次疟疾发作的儿童(病例)和没有疟疾发作的儿童(对照)中蠕虫感染的优势比。5岁、6~10岁和11~15岁儿童中，分别有82例(23.2%)、16例(2.2%)和17例(4.7%)感染疟疾(P=0.001)。病例组蠕虫感染率为21/115(18.3%)，对照组为456/1327(34.4%)。按年龄组分层的病例与对照组蠕虫感染的加权优势比为0.50(95%可信区间=0.2-0.84，P<；0.01)。以蛔虫和钩虫为主，分别为14例(12.2%)和6例(5.2%)，对照组分别为333例(25.1%)和132例(10.0%)(P=0.001)。蠕虫感染和疟疾之间的负关联可能在驱虫计划的设计中具有重要意义。
The relationship between intestinal helminth infection and susceptibility to malaria remains unclear. We studied the relationship between these infections. Seven schools in Ilero, Nigeria referred all pupils with febrile illness to our study center for free malaria treatment during a 3-month study period. At the end, all pupils submitted a stool sample for microscopic investigation for helminth eggs. We used an unmatched case-control design to calculate the odds ratios for helminth infection in children with at least one attack of malaria (cases) and children with no malaria episodes during the study (controls). We recorded 115 malaria cases in 82 of 354 (23.2%), 16 of 736 (2.2%), and 17 of 348 (4.7%) children ages 5, 6-10, and 11-15 years old, respectively (P = 0.001). Helminth infection rate in cases was 21 of 115 (18.3%) compared with 456 of 1,327 (34.4%) in controls. Weighted odds ratio stratified by age group for helminth infection in cases versus controls was 0.50 (95% confidence interval = 0.2-0.84, P < 0.01). Ascaris and hookworm were the most common helminths detected, with prevalence rates of 14 (12.2%) and 6 (5.2%) among cases compared with 333 (25.1%) and 132 (10.0%) in controls, respectively (P = 0.001). The negative association between helminth infection and malaria may be of importance in the design of deworming programs.