Anti-Swelling, Robust, and Adhesive Extracellular Matrix-Mimicking Hydrogel Used as Intraoral Dressing
Anti-Swelling, Robust, and Adhesive Extracellular Matrix-Mimicking Hydrogel Used as Intraoral Dressing
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用作口内敷料的抗肿胀、坚固且具有粘性的模拟细胞外基质水凝胶。
DOI：
10.1002/adma.202200115
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发表时间：
2022-04-14
影响因子：
29.4
通讯作者：
Zou, Duo-Hong
中科院分区：
文献类型：
--
作者：
Wu, Jing;Pan, Zhao;Zou, Duo-Hong
由于口腔的潮湿和动态环境，口腔内伤口（例如拔牙伤口）的愈合需要稳定且牢固的伤口敷料。在临床实践中，棉球和纱布、海绵塞或缝线用于治疗拔牙伤口，但这些方法都不能持续将伤口与口内环境隔离并促进理想的愈合条件。在此，受天然细胞外基质的启发，开发了一系列用于口内伤口修复的伤口敷料。将韧性长链水凝胶网络渗透到预制的、坚固的大分子网络中并原位交联，赋予复合水凝胶可控的溶胀行为和稳健的力学性能。大分子网络作为骨架支撑复合材料并限制长链水凝胶网络的溶胀。体外试验证实，该伤口敷料可为口内伤口提供持久保护，免受复杂刺激。此外，当伤口敷料在犬拔牙模型上体内应用时，由于急性炎症的有效减少，伤口愈合加速。这些结果表明，这一系列的生物启发水凝胶作为口腔内伤口敷料具有很大的应用潜力。
Due to the wet and dynamic environment of the oral cavity, the healing of intraoral wounds, such as tooth extraction wounds, requires stable and firm wound dressings. In clinical practice, cotton balls and gauzes, sponge plugs, or sutures are used to treat extraction wounds, but none of these means can continuously isolate the wound from the intraoral environment and facilitate ideal healing conditions. Herein, inspired by the natural extracellular matrix, a family of wound dressings is developed for intraoral wound repair. Infiltrating a ductile long-chain hydrogel network into a prefabricated, sturdy macromolecular meshwork and in situ crosslinking endowed the composite hydrogel with controllable swelling behaviors and robust mechanical properties. The macromolecular meshwork functioned as the backbone to support the composite and restricts the swelling of the long-chain hydrogel network. In vitro tests verified that this wound dressing can provide durable protection for intraoral wounds against complex irritations. Furthermore, accelerated wound healing occurred when the wound dressing is applied in vivo on a canine tooth extraction model, due to the effective reduction of acute inflammation. These results suggest that this family of bioinspired hydrogels has great potential for application as intraoral wound dressing.