Global causes of diarrheal disease mortality in children <5 years of age: a systematic review.
Global causes of diarrheal disease mortality in children <5 years of age: a systematic review.
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DOI：
10.1371/journal.pone.0072788
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Child Health Epidemiology Reference Group of the World Health Organization and UNICEF
中科院分区：
文献类型：
--
作者：
Lanata CF;Fischer-Walker CL;Olascoaga AC;Torres CX;Aryee MJ;Black RE;Child Health Epidemiology Reference Group of the World Health Organization and UNICEF
需要估计儿童腹泻死亡的病原体特异性原因，以指导疫苗开发和其他预防策略。我们对1990年至2011年期间发表的文章进行了系统回顾，这些文章报告了13种病原体中至少有一种在5岁以下因腹泻住院的儿童中。我们纳入了来自世卫组织协调的轮状病毒监测网络的2011年轮状病毒数据。我们排除了在腹泻爆发期间进行的研究，这些研究没有区分住院和门诊病例，报告了医院感染，在特殊人群中进行的研究，没有采用适当的方法，以及在使用轮状病毒疫苗的国家进行的轮状病毒研究。计算了每种病原体的中位数比例，并将其应用于2011年5岁以下儿童中因腹泻而死亡的712，000例，假设在因腹泻住院的儿童中观察到的那些代表导致儿童腹泻死亡的病原体。选择了在31个国家完成的163篇文章和WHO研究，代表286项住院研究。仅寻找一种病原体的研究发现，某些病原体的比例高于寻找多种病原体的研究（例如，180项单一病原体研究中的轮状病毒比例为39%，而24项5-13种病原体研究中的轮状病毒比例为20%，p<0.0001）。未发现病原体的病例百分比估计为34%;所有年龄校正的病原体和无病原体病例百分比总和为138%。调整所有的比例，包括未知数，增加到100%，我们估计轮状病毒引起197 000 [不确定性范围（UR）110 000-295 000]，肠致病性大肠杆菌。coli 79000（UR 31000 - 146000）、杯状病毒71000（UR 39000 - 113000）和产肠毒素E.大肠杆菌42 000例（UR 20 000-76 000）死亡。轮状病毒、杯状病毒、肠致病性和肠致病性E.大肠杆菌导致全世界5岁以下儿童半数以上的肺炎死亡。
Estimation of pathogen-specific causes of child diarrhea deaths is needed to guide vaccine development and other prevention strategies. We did a systematic review of articles published between 1990 and 2011 reporting at least one of 13 pathogens in children <5 years of age hospitalized with diarrhea. We included 2011 rotavirus data from the Rotavirus Surveillance Network coordinated by WHO. We excluded studies conducted during diarrhea outbreaks that did not discriminate between inpatient and outpatient cases, reporting nosocomial infections, those conducted in special populations, not done with adequate methods, and rotavirus studies in countries where the rotavirus vaccine was used. Age-adjusted median proportions for each pathogen were calculated and applied to 712 000 deaths due to diarrhea in children under 5 years for 2011, assuming that those observed among children hospitalized for diarrhea represent those causing child diarrhea deaths. 163 articles and WHO studies done in 31 countries were selected representing 286 inpatient studies. Studies seeking only one pathogen found higher proportions for some pathogens than studies seeking multiple pathogens (e.g. 39% rotavirus in 180 single-pathogen studies vs. 20% in 24 studies with 5–13 pathogens, p<0·0001). The percentage of episodes for which no pathogen could be identified was estimated to be 34%; the total of all age-adjusted percentages for pathogens and no-pathogen cases was 138%. Adjusting all proportions, including unknowns, to add to 100%, we estimated that rotavirus caused 197 000 [Uncertainty range (UR) 110 000–295 000], enteropathogenic E. coli 79 000 (UR 31 000–146 000), calicivirus 71 000 (UR 39 000–113 000), and enterotoxigenic E. coli 42 000 (UR 20 000–76 000) deaths. Rotavirus, calicivirus, enteropathogenic and enterotoxigenic E. coli cause more than half of all diarrheal deaths in children <5 years in the world.
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影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.
影响因子：
168.9
作者：
Liu, Li;Johnson, Hope L.;Black, Robert E.
通讯作者：
Black, Robert E.
DOI：
10.1093/cid/cis762
发表时间：
2012-12
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Muhsen K;Levine MM
通讯作者：
Levine MM
影响因子：
9.4
作者：
BRANDT, CD;KIM, HW;CHANOCK, RM
通讯作者：
CHANOCK, RM