Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells
Development of CD4+ macrophages from intrathymic T cell progenitors is induced by thymic epithelial cells
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DOI：
10.4049/jimmunol.173.7.4360
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发表时间：
2004-10-01
影响因子：
4.4
通讯作者：
Miyajima, A
中科院分区：
文献类型：
--
作者：
Esashi, E;Ito, H;Miyajima, A
最近有研究表明，胸腺中存在CD4（+）巨噬细胞，具有很强的吞噬活性。提示它们在消除胸腺细胞凋亡中起重要作用。然而，CD4（+）巨噬细胞在胸腺中的来源和性质仍不清楚。在这项研究中，我们描述了最不成熟的胸腺内祖细胞(CD25(-)/CD44（+)/FcR(+)）通过抑素m应答胸腺上皮细胞产生CD4（+）巨噬细胞。（ORTEC）依赖于il -7。ORTEC条件培养基和细胞因子混合物均未诱导CD4（+）巨噬细胞和癌抑素M受体在胸腺细胞中表达，这表明未成熟胸腺细胞中CD4（+）巨噬细胞的发育需要与ORTEC直接相互作用。这些结果共同表明，胸腺上皮细胞诱导胸腺内T细胞祖细胞产生CD4（+）巨噬细胞。
It was recently demonstrated that there are CD4(+) macrophages, which exhibit strong phagocytic activity, in the thymus. They are suggested to play an important role for the elimination of apoptotic thymocytes. However, the origin and nature of CD4(+) macrophages in the thymus remain unexplored. In this study, we describe that the most immature intrathymic progenitors (CD25(-)/CD44(+)/FcR(+)) give rise to CD4(+) macrophages by oncostatin M-responsive thymic epithelial cells.(ORTEC) in an IL-7-dependent manner. Neither conditioned medium of ORTEC nor a mixture of cytokines induced CD4(+) macrophages, and oncostatin M receptor was not expressed in thymocytes, suggesting that the development of CD4(+) macrophages from the immature thymocytes requires a direct interaction with ORTEC. These results collectively suggest that the development of CD4(+) macrophages from the intrathymic T cell progenitors is induced by thymic epithelial cells.