Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the pulse trauma work group
Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: Report of the pulse trauma work group
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DOI：
10.1097/00024382-200203000-00001
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发表时间：
2002-03-01
期刊：
影响因子：
3.1
通讯作者：
Chaudry, IH
中科院分区：
文献类型：
--
作者：
Carrico, CJ;Holcomb, JB;Chaudry, IH
创伤性损伤及其后遗症在北美仍然是一个重大的、未被认识到的公共卫生问题。它是导致1-44岁患者死亡的主要原因，也是美国人少活几年的主要原因。认识到这一点，国家心肺和血液研究所(NHLBI)与其他联邦机构在2000年6月组织了一次会议，讨论基础和临床研究项目，这些项目可以改善心肺复苏或损伤后复苏的结果。随后成立了救生努力的复苏和初始效用(PULSE)研讨会，并成立了八个工作组，重点关注器官系统、药理学、流行病学和创伤等不同方面。创伤工作组的建议在这份手稿中提出。尽管人们认识到创伤系统和创伤护理的进步改善了存活率和预后，但美国国立卫生研究院(NIH)对创伤研究的支持比率仅为0.10，相比之下，癌症研究的支持比率为1.65，艾滋病和艾滋病毒感染研究的支持比率则高达3.51。成功的联邦艾滋病毒研究计划在过去十年中显著降低了发病率和死亡率，每年花费14亿美元。一个协调的创伤研究项目应该旨在复制此类项目所取得的成功；然而，一个集中化的联邦创伤研究“家”并不存在。因此，现有的有限的研究支持来自NIH研究所以及其他联邦和州机构。这份报告描述了一些障碍，并概述了基础科学、临床和转化性创伤复苏研究的各种战略和优先事项。
Traumatic injury and its sequelae remains a major, unrecognized, public health problem in North America. It is the principle cause of death in patients aged 1-44 and the overall leading cause of life years lost in the United States. Recognizing this the National Heart, Lung and Blood Institute (NHLBI), in conjunction with other federal agencies, organized a conference in June 2000 to discuss the basic and clinical research projects that could lead to improved outcomes following cardiopulmonary or post-injury resuscitation. The Post Resuscitative and Initial Utility of Life Saving Efforts (PULSE) Workshop resulted and eight workgroups were established to focus on various aspects including organ systems, pharmacology, epidemiology, and trauma. The Trauma Work group recommendations are presented in this manuscript. Despite the recognition of improved survival and outcome through advancements in trauma systems and trauma care, the National Institutes of Health (NIH) support ratio for trauma research is only 0.10 compared to 1.65 for cancer research and a remarkable support ratio of 3.51 for AIDS and HIV infection research. The successful federal HIV research program has significantly decreased the morbidity and mortality over the last ten years at a cost of 1.4 billion dollars per year. A coordinated trauma research program should aim to replicate the success achieved by such programs; however, a centralized federal "home" for trauma research does not exist. Consequently, the existing limited research support is derived from NIH institutes in addition to other federal and state agencies. This report serves to describe some of the obstacles and to outline various strategies and priorities for basic science, clinical and translational trauma resuscitation research.