Relation between body mass index and cognitive function in healthy middle-aged men and women
Relation between body mass index and cognitive function in healthy middle-aged men and women
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DOI：
10.1212/01.wnl.0000238082.13860.50
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发表时间：
2006-10-10
期刊：
影响因子：
9.9
通讯作者：
Ruidavets, J. -B.
中科院分区：
文献类型：
--
作者：
Cournot, M.;Marquie, J. -C.;Ruidavets, J. -B.
目的：评估体重指数（BMI）是否与健康男性和女性的认知功能和认知能力下降相关。方法：在这项前瞻性队列研究中，我们分析了 2,223 名 32 至 62 岁健康工人的基线数据。 1996 年和 2001 年收集了医学、社会心理和环境数据。我们在基线和后续阶段通过单词列表学习（四次回忆）、数字符号替换测试和选择性注意力测试测试了认知功能。结果：从横截面来看，在调整年龄、性别、教育水平、血压、糖尿病和其他社会心理协变量后，较高的 BMI 与较低的认知得分相关。在调整上述混杂因素后，基线时较高的 BMI 也与随访时较高的认知能力下降相关。这种关联对于单词列表学习非常重要。对于单词表学习（延迟回忆）的分数变化，与第一个五分位数相比，基线时 BMI 第二、第三、第四和第五五分位数的回归系数分别为 -0.008 +/- 0.13、-0.09 +/- 0.13、-0.17 +/- 0.14 和 0.35 +/- 0.14（趋势 p < 0.001）。 BMI 变化与认知功能之间没有发现显着关联。结论：健康、非痴呆的中年男性和女性的体重指数与认知功能（单词列表学习和数字符号替换测试）以及单词列表学习的变化独立相关。
Objective: To assess whether body mass index (BMI) is associated with cognitive function and cognitive decline in healthy men and women. Methods: In this prospective cohort study, we analyzed data from 2,223 healthy workers aged 32 to 62 years at baseline. Medical, psychosocial, and environmental data were collected in 1996 and in 2001. We tested cognitive functions at baseline and at follow-up with word-list learning (four recalls), a Digit-Symbol Substitution Test, and a selective attention test. Results: Cross-sectionally, a higher BMI was associated with lower cognitive scores after adjustment for age, sex, educational level, blood pressure, diabetes, and other psychosocial covariables. A higher BMI at baseline was also associated with a higher cognitive decline at follow-up, after adjustment for the above-cited confounding factors. This association was significant for word-list learning. For the changes in scores at word-list learning (delayed recall), regression coefficients were -0.008 +/- 0.13, -0.09 +/- 0.13, -0.17 +/- 0.14, and 0.35 +/- 0.14 (p for trend < 0.001) for the second, third, fourth, and fifth quintiles of BMI at baseline when compared with the first quintile. No significant association was found between changes in BMI and cognitive function. Conclusions: Body mass index was independently associated both with cognitive function (word-list learning and Digit-Symbol Substitution Test) and changes in word-list learning in healthy, nondemented, middle-aged men and women.