Myelination Is Associated with Processing Speed in Early Childhood: Preliminary Insights.
Myelination Is Associated with Processing Speed in Early Childhood: Preliminary Insights.
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DOI：
10.1371/journal.pone.0139897
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
LeBourgeois MK
中科院分区：
文献类型：
--
作者：
Chevalier N;Kurth S;Doucette MR;Wiseheart M;Deoni SC;Dean DC 3rd;O'Muircheartaigh J;Blackwell KA;Munakata Y;LeBourgeois MK
处理速度是幼儿工作记忆表现和流体智力的重要因素。有髓鞘白质在大脑信息传递中发挥着核心作用，并可能调节处理速度，但人们对幼儿的髓鞘化和处理速度之间的关系知之甚少。在本研究中，通过检查时间来测量处理速度，并使用多分量磁共振成像 (MRI) 方法对 2 至 5 岁的髓磷脂体积分数 (VFM) 进行量化。检查时间和 VFM 都随着年龄的增长而增加。在控制年龄后，左右枕叶、胼胝体和右侧小脑的更大 VFM 与更短的检查时间显着相关。分层回归表明，左枕叶的 VFM 预测检查时间的效果超出了年龄和其他大脑区域的 VFM 的影响。这些发现与髓磷脂支持幼儿期处理速度的假设是一致的。
Processing speed is an important contributor to working memory performance and fluid intelligence in young children. Myelinated white matter plays a central role in brain messaging, and likely mediates processing speed, but little is known about the relationship between myelination and processing speed in young children. In the present study, processing speed was measured through inspection times, and myelin volume fraction (VFM) was quantified using a multicomponent magnetic resonance imaging (MRI) approach in 2- to 5-years of age. Both inspection times and VFM were found to increase with age. Greater VFM in the right and left occipital lobes, the body of the corpus callosum, and the right cerebellum was significantly associated with shorter inspection times, after controlling for age. A hierarchical regression showed that VFM in the left occipital lobe predicted inspection times over and beyond the effects of age and the VFM in the other brain regions. These findings are consistent with the hypothesis that myelin supports processing speed in early childhood.