Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma
Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma
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DOI：
10.1007/s11033-014-3201-y
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发表时间：
2014-05-01
影响因子：
2.8
通讯作者：
Li, Li
中科院分区：
文献类型：
--
作者：
Jin, Shaoju;Mu, Yishuang;Li, Li
RACK1是一种重要的支架和锚定蛋白，在肿瘤发生的多种信号通路中起着至关重要的作用。本研究的目的是确定RACK1表达与结直肠癌（CRC）患者恶性程度之间的关系。共纳入157例结直肠癌患者，并对其临床资料进行分析。分别采用RT-PCR、Western-blot和免疫组织化学检测RACK1在结直肠癌和癌周组织中的表达。评估RACK1表达与组织学分级及淋巴结转移的相关性。结果显示，RACK1的表达与结直肠癌患者的分化水平和淋巴结转移呈正相关。
RACK1 is a crucial scaffold and anchoring protein, which plays a vital role in multiple signaling pathways of tumorigenesis. The aim of the present study was to identify the correlation between expressions of RACK1 and malignant degrees in colorectal carcinoma (CRC) patients. All together 157 CRC patients were enrolled, and their clinical data were analyzed. Expressions of RACK1 in CRC and pericarcinous tissues in these patients were determined by RT-PCR, Western-blot, and immunohistochemistry, respectively. The correlation between RACK1 expressions and histological grades, as well as lymph node metastasis was evaluated. Results showed that the expressions of RACK1 were positively correlated with differentiation level and lymph node metastasis in CRC patients.