Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: A double-blind, randomized, parallel group, dose-ranging study
Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: A double-blind, randomized, parallel group, dose-ranging study
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DOI：
10.1016/j.jpainsymman.2007.12.005
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发表时间：
2008-05-01
影响因子：
4.7
通讯作者：
Israel, Robert J.
中科院分区：
文献类型：
--
作者：
Portenoy, Russell K.;Thomas, Jay;Israel, Robert J.
Methylnaltrexone, a peripherally-acting quaternary opioid antagonist, is an investigational treatment for opioid-induced constipation in patients with advanced illness. This randomized, parallel-group, repeated dose, dose-ranging trial included a double-blind phase for one week followed by an open-label phase for a maximum of three weeks. Opioid-treated patients with advanced illness who met criteria for opioid-induced constipation despite laxative therapy were potentially eligible. Double-blind treatment occurred on Days 1, 3, and 5; open-label therapy could. be administered as often as every other day. The initial dose range of 1 mg, 5 mg, or 12.5 mg was extended by adding a 20 mg group during the study while still maintaining the double blind; the initial open-label dose of 5 mg could be titrated. The primary outcome was a taxation response within four hours after the first dose. Thirty-three patients received at least one dose of methylnaltrexone. Only one of 10 patients (10%) who received the I mg dose experienced laxation within four hours of dosing. The median time to laxation was >48 hours for the I mg dose group, compared to L 26 hours for all patients receiving >= 5 mg (P=0.0003). There was no apparent dose-response above 5 mg. Most adverse events were related to the gastrointestinal system, were mild., and did not lead to discontinuation. In conclusion, methylnaltrexone relieved opioid-induced constipation at doses >= 5 mg in patients with advanced illness, and did not reduce analgesia or cause opioid withdrawal symptoms.
