Role of glycosaminoglycans in infectious disease.
Role of glycosaminoglycans in infectious disease.
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DOI：
10.1007/978-1-4939-1714-3_45
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Park PW
中科院分区：
文献类型：
--
作者：
Jinno A;Park PW
Glycosaminoglycans (GAGs) have been shown to bind to a wide variety of microbial pathogens, including viruses, bacteria, parasites, and fungi in vitro. GAGs are thought to promote pathogenesis by facilitating pathogen attachment, invasion, or evasion of host defense mechanisms. However, the role of GAGs in infectious disease has not been extensively studied in vivo and therefore their pathophysiological significance and functions are largely unknown. Here we describe methods to directly investigate the role of GAGs in infections in vivo using mouse models of bacterial lung and corneal infection. The overall experimental strategy is to establish the importance and specificity of GAGs, define the essential structural features of GAGs, and identify a biological activity of GAGs that promotes pathogenesis.
