Growing evidence for diabetes susceptibility genes from genome scan data.
Growing evidence for diabetes susceptibility genes from genome scan data.
复制标题
DOI：
10.1007/s11892-003-0040-y
复制
发表时间：
2003-04-01
影响因子：
4.2
通讯作者：
McCarthy, Mark I
中科院分区：
文献类型：
--
作者：
McCarthy, Mark I
全基因组连锁扫描提供了研究人员在努力识别负责2型糖尿病易感性遗传成分的基因时所采用的主要方法之一。目前已经完成了大约20次基因组扫描，涉及各种人群。整合来自这些不同扫描的数据已被证明绝非易事，但全基因组连锁拓扑学的轮廓正从数据的迷雾中稳步浮现。钙蛋白酶-10基因作为墨西哥裔美国人染色体2 q连锁的可能基础的鉴定为这种定位克隆方法提供了验证。本报告提供了最近2型糖尿病基因组扫描数据的更新，重点是几个染色体区域，在过去的一年中，这些区域的联系证据大大加强。全基因组连锁信息在寻找2型糖尿病易感性影响的当前和未来的价值也进行了讨论。
Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain-10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed.