Changes in Anterior Segment Morphology After Laser Peripheral Iridotomy in Acute Primary Angle Closure
Changes in Anterior Segment Morphology After Laser Peripheral Iridotomy in Acute Primary Angle Closure
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DOI：
10.1016/j.ajo.2016.03.032
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发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Lin, Shan C.
中科院分区：
文献类型：
--
作者：
Moghimi, Sasan;Chen, Rebecca;Lin, Shan C.
目得：目的：评价激光周边虹膜切开术（LPI）治疗急性原发性房角关闭（APAC）后，眼前节光学相干断层扫描（AS-OCT）测量的眼前节生物计量学变化。设计：前瞻性干预研究。受试者在LPI前和LPI后6周接受了完整的眼科检查和AS-OCT成像。测量LPI前后的前房深度（ACD）、前房面积（ACA）、虹膜厚度（IT）、虹膜面积、虹膜曲率、透镜穹窿（LV）、前穹窿、房角开放距离（AOD 500、AOD 750）、虹膜小梁间隙面积（TISA 500、TISA 750）。对AOD 750变化的潜在预测因素进行了线性混合模型分析。主要结果测量是LPI后AOD 750的变化。结果：参与者的平均年龄为60.7 ± 9.2岁。平均角宽度（Shaffer分级）从基线时的0.25 ± 0.34变为LPI后的1.22 ± 0.86（P <0.001）。然而，25个鼻角（48.0%）和28个颞角（53%）在LPI后有虹膜小梁接触。所有角度参数（AOD 500、AOD 750、TISA 500、TISA 750; P
PURPOSE: To evaluate the anterior segment biometric changes measured by anterior segment optical coherence tomography (AS-OCT) in acute primary angle closure (APAC) after laser peripheral iridotomy (LPI).DESIGN: Prospective interventional study.METHODS: In this clinic-based study, 52 eyes of 52 patients with resolved APAC attack who underwent LPI were enrolled. Subjects underwent complete ophthalmic examination and AS-OCT imaging before and 6 weeks after LPI. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness (IT), iris area, iris curvature, lens vault (LV), anterior vault, angle opening distance (AOD500, AOD750), and trabecular iris space area (TISA500, TISA750) were measured in qualified images and compared before and after LPI. A linear mixed-model analysis was performed for potential predictors of change in AOD750. Main outcome measure was change in AOD750 after LPI.RESULTS: The mean age of participants was 60.7 +/- 9.2 years. Mean angle width (Shaffer grade) changed from 0.25 +/- 0.34 at baseline to 1.22 +/- 0.86 after LPI (P < .001). However, 25 nasal angles (48.0%) and 28 temporal angles (53%) had iridotrabecular contact after LPI. All angle parameters (AOD500, AOD750, TISA500, TISA750; P